Doctoral Candidate in Immunology: The IMMERGE MSCA Doctoral Network (DN) offers an exceptional training initiative that spans multiple domains of knowledge, focusing on Immunology, Epigenetics, Omics, Gene Editing Technologies, and Bioinformatics. The program seeks to recruit 12 outstanding Doctoral Candidates (DCs) to answer key questions related to Inborn Errors of Immunity (IEI).
Doctoral Candidate in Immunology, Epigenetics, and Gene Editing Technologies
- 🏥 Host Institution: Ospedale San Raffaele SRL (OSR), Italy (Milan)
- 📅 Open Call: April 4th, 2024
- 📝 Application Deadline: May 20th, 2024, 12.00 PM (CET)
- 🇪🇺 EU Research Framework Program: Horizon Europe Marie Sklodowska Curie Actions Doctoral Networks
- 📜 Grant Agreement Number: 101119927
- 🌐 About IMMERGE MSCA Doctoral Network (DN):
- Offers 12 Doctoral Candidate (DC) positions in Immunology, Epigenetics, Omics, Gene Editing Technologies, and Bioinformatics.
- Aims to address questions on Inborn Errors of Immunity (IEI) regarding genetic mutations, clinical phenotypic expressivity, and drug response.
- 🧬 Individual Research Project – Doctoral Candidate 6:
- Host Institution: Ospedale San Raffaele SRL, Milan (Italy)
- Degree Awarding Institution: Università Vita-Salute San Raffaele, Milan
- Supervisor: Dr. Raffaella Di Micco
- Investigates the role of dysfunctional telomeres in stem cell biology and immunity.
- 📋 Requirements – Eligibility Criteria:
- Open to Doctoral Candidates worldwide meeting specific criteria.
- Must not hold a doctoral degree at the time of recruitment.
- Must not have resided in the recruiting country for more than 12 months in the past 36 months.
- Proficiency in English and relevant qualifications required.
- 📝 Additional Information – Application and Selection Process:
- Applications submitted through the IMMERGE recruitment platform and a Microsoft Form.
- Eligible applications ranked based on CVs and merits by selection committees.
- Evaluation criteria include academic merit, experience, mobility, and publication track record.
- 🗓️ Timeline (Tentative):
- Open Application: April 4th, 2024
- Application Deadline: May 20th, 2024
- Recruitment Workshop: Mid-June, 2024
- Tentative Start of Fellowship: September, 2024
- 💼 Benefits:
- 3-year full-time employment contract with salary depending on country regulations.
- Enrollment in a PhD program, shared research, and innovative multidisciplinary training.
- Structured training program, secondments, gaining experience abroad, and professional networking opportunities.
- ℹ️ Further Information:
- Visit www.immergeproject.eu or contact immerge@carrerasresearch.org for inquiries.
- Project funded by the European Union’s Horizon Europe research and innovation program under Marie Sklodowska-Curie grant agreement No 101119927.
Summary Table
| Designation | Doctoral Candidate 6: Dissecting the Role of Dysfunctional Telomeres in Stem Cell Biology and Immunity |
|---|---|
| Research Area | Immunology, Epigenetics, Omics, Gene Editing Technologies, Bioinformatics |
| Location | Ospedale San Raffaele SRL, Milan, Italy |
| Eligibility/Qualification | Master’s degree in relevant field, high proficiency in English |
| Job Description | Research on telomere biology and immune dysfunctions, training, secondments |
| How to Apply | Online via IMMERGE website and Microsoft Form |
| Last Date for Apply | May 20, 2024 |
Designation
Doctoral Candidate 6: Dissecting the Role of Dysfunctional Telomeres in Stem Cell Biology and Immunity
Research Area
Immunology, Epigenetics, Omics, Gene Editing Technologies, Bioinformatics
Location
Host Institution: Ospedale San Raffaele SRL
Degree Awarding Institution: Università Vita-Salute San Raffaele, Milan, Italy
Eligibility/Qualification
- Must not hold a doctoral degree at the recruitment date.
- Must not have resided or worked in the country of the recruiting organization for more than 12 months in the 36 months before the recruitment date.
- Must have a relevant master’s degree or equivalent qualification.
- High proficiency in written and spoken English.
Job Description
The candidate will focus on Dyskeratosis congenita (DC), a genetic syndrome characterized by short telomeres, and will investigate the underlying mechanisms of bone marrow failure and immune dysfunctions. The project involves creating a DC human model using CRISPR-Cas9 to study the effects of telomere shortening on hematopoietic stem and progenitor cells (HSPC). The research will include:
- Imaging and flow cytometry to examine DNA damage response (DDR).
- Single-cell RNA sequencing and histone mark analysis for transcriptional and epigenetic changes.
- Luminex assays for proinflammatory phenotype assessment.
- Functional experiments with colony-forming assays and long-term hematopoietic reconstitution.
- Validation with patient-derived HSPCs in collaboration with Gaslini Hospital, Genoa.
How to Apply
Applicants must submit their applications through both the recruitment platform (Personio) available on the IMMERGE website and a Microsoft Form to ensure eligibility. The following documents are required:
- CV
- Motivation letter specific to the position
Applications must be submitted in English.
Last Date for Apply
May 20, 2024, at 12:00 PM (CET)
Additional Information
- 3-year full-time employment contract
- Enrolment in a PhD program
- Multidisciplinary and multisectoral training
- Secondments at various institutions within the IMMERGE consortium
- Participation in national and international meetings
- Networking opportunities
For more details, visit IMMERGE Project or contact via email at immerge@carrerasresearch.org or phone at (+34) 93 557 2800 (ext. 4252).
