PhD in Modeling Organoids: The German Cancer Research Center (DKFZ) invites applications for a PhD position focused on novel models of medulloblastoma using cerebellar organoids. This research project is part of the “Developmental Origins of Pediatric Cancer” junior group, aiming to create and characterize innovative preclinical models to improve treatment outcomes for children with this aggressive form of cancer.
PhD in Modeling Pediatric Cancer Using Cerebellar Organoids
Designation
PhD Student in Modeling Pediatric Cancer
| Attribute | Details |
|---|---|
| Research Area | Medulloblastoma, Pediatric Cancer, Cerebellar Organoids |
| Location | Heidelberg, Germany |
| Eligibility/Qualification | – Master’s or Bachelor’s degree in a relevant field – Experience or motivation in brain development or cancer mechanisms (preferred but not required) – Practical experience in cell culture, molecular biology, or animal work (preferred but not required) |
| Job Description | – Build and characterize preclinical models derived from human cerebellar organoids. – Investigate how different oncodrivers affect developmental pathways and promote tumorigenesis. – Engage in 20-30% mouse work alongside lab activities. |
| How to Apply | Submit a cover letter describing your motivation, CV, MSc/BSc transcripts, and contact information for two references via the online application tool at DKFZ. |
| Last Date to Apply | January 9, 2025 |
Research Area
The project focuses on medulloblastoma, a significant pediatric cancer associated with high mortality rates among children. The aim is to understand the heterogeneity of this disease and to develop more accurate preclinical models for better treatment strategies.
Location
- Institute: German Cancer Research Center (DKFZ)
- City: Heidelberg, Germany
Eligibility/Qualification
- A Master’s or Bachelor’s degree in a relevant field.
- Experience in brain development or cancer mechanisms is desired but not mandatory.
- Practical experience in cell culture, ideally iPSC or organoid technologies, and molecular biology is preferred but not required.
Job Description
- Construct, characterize, and implement innovative preclinical models of medulloblastoma using human cerebellar organoids.
- Analyze how various oncodrivers impact developmental trajectories initiating tumor growth.
- Work both independently and collaboratively within a diverse, international team.
How to Apply
Interested candidates should submit their application, including:
- A cover letter/letter of motivation
- CV
- MSc/BSc transcripts
- Contact details of 2 references
Applications should be submitted via the DKFZ online application portal, as email applications will not be accepted.
Last Date to Apply
- Application Deadline: January 9, 2025
This PhD opportunity promises a supportive and enriching environment, aiming at groundbreaking research that contributes to a future without cancer. Join us in this innovative endeavor!
