PhD Position in Mechanobiology: The University Hospital Jena is inviting applications for a PhD position focused on mechanobiological interactions between parasites and host cells, as part of the DFG-funded research program “Physics of Parasitism” (SPP 2332). This project aims to develop innovative models to understand pathogenic effects of mechanical forces in worm infections.
PhD Position in Mechanobiology of Parasitic Interactions
Designation
PhD Candidate (m/f/d) in Mechanobiology of Parasitic Interactions
Research Area
- Mechanobiology
- Parasitology
- Molecular Biology
- Cell Biology
Location
University Hospital Jena, Germany
Eligibility/Qualification
- Completed scientific university degree (Master’s or Diploma) in Life Sciences, Biophysics, Molecular Biology, Biotechnology, Biochemistry, or related fields.
- Interest in parasitological research, cell biology, and biophysics.
- Experience in cell culture, fluorescence microscopy, and/or microfluidic techniques is desirable.
- Team-oriented with self-initiation and careful working style.
- Excellent German or English language skills (minimum C1 level).
Description
The selected candidate will:
- Develop and apply a worm-on-chip model to study the suction forces of trematodes, specifically Schistosoma mansoni and Fasciola hepatica.
- Cultivate liver and endothelial cell lines (e.g., HepaRG, LSEC) on hydrogel-functionalized surfaces.
- Conduct Traction Force Microscopy (TFM) and Monolayer Stress Microscopy (MSM) to quantify parasitic forces on host cell layers.
- Analyze mechanosensitive signaling pathways in host cells, including calcium imaging and molecular biological analyses (qRT-PCR, immunofluorescence).
- Collaborate on interdisciplinary research to establish a microfluidic system simulating physiological niches (e.g., liver sinusoids, bile ducts).
How to Apply
Interested candidates should submit their applications, including a CV and cover letter, to PD Dr. Alexander Mosig via the provided contact number or email.
Last Date for Application
Until position filled
