Postdoctoral Researcher in 3D Genome Architecture: The Institute of Molecular Biology and Biotechnology (IMBB), Faculty of Biology & Centre of Advanced Technologies at Adam Mickiewicz University in Poznań, Poland, invites applications for a Postdoctoral Researcher position under the NCN/DFG OPUS-LAP collaborative project (No. 2024/55/I/NZ5/03165) in partnership with the University of Göttingen, Germany.
The successful candidate will join the Developmental Epigenetics Lab led by Dr hab. Michał R. Gdula and collaborate with Prof. Argyris Papantonis to investigate 3D genome re-organization during induced senescence in pancreatic cancer. This is a full-time, three-year funded position supported by the Polish National Science Centre (NCN) and the German Research Foundation (DFG).
Postdoctoral Researcher in 3D Genome Architecture & Pancreatic Cancer
Summary Table
| Category | Details |
|---|---|
| Position | Postdoctoral Researcher |
| Project Title | 3D genome re-organization during induced senescence in pancreatic cancer |
| Institution | Institute of Molecular Biology and Biotechnology, AMU |
| Collaboration | University of Göttingen, Germany |
| Funding | NCN/DFG OPUS-LAP |
| Location | Poznań, Poland |
| Duration | 3 years (1+2 year contract) |
| Salary | ~112,000 PLN gross/year (8,987 PLN/month + 13th salary; 140,000 PLN “brutto brutto”) |
| Start Date | 1 May 2026 |
| Application Deadline | 20 March 2026 |
Designation
Postdoctoral Researcher (Full-Time)
Research Area
- Epigenetics
- 3D Genome Architecture
- Chromatin Biology
- Pancreatic Cancer (PDAC)
- Functional Genomics
- Long-read Nanopore Sequencing
Location
Poznań, Poland
Faculty of Biology & Centre of Advanced Technologies, Adam Mickiewicz University
Project Description
Project Title:
“3D genome re-organization during induced senescence in pancreatic cancer – insights from analysis of single chromatin fibers.”
This project builds upon previous discoveries demonstrating that HMGB2 loss drives genome architecture changes enforcing senescence. The study aims to:
- Investigate interactions of HMGB2 and upstream regulators
- Examine transcriptional and epigenomic remodeling in pancreatic cancer organoids
- Identify structural biomarkers using long-read Nanopore sequencing
Experimental Approaches:
- Capture-C, Micro-C, PORE-C
- WGBS methylome profiling
- DamID (Lamin association)
- CUT&RUN (H3K9me3 enrichment)
- RNA-seq, ChIP-seq
- Single chromatin fiber multimodal mapping
Job Description / Responsibilities
- Lead and manage an independent research project
- Plan and perform molecular biology and cell culture experiments
- Conduct computational analysis of NGS and Nanopore sequencing data
- Present findings in lab meetings, seminars, and international conferences
- Prepare manuscripts for peer-reviewed journals
Eligibility / Qualifications
Essential:
- PhD in Molecular Biology, Genetics, or related field
- Strong background in molecular biology/biochemistry techniques
- Experience with genomic experiments (RNA-seq, ChIP-seq, WGBS, etc.)
- At least one first-author peer-reviewed publication in a relevant field
- Demonstrated independent research capability
- Excellent communication skills
- Fluency in English
Desirable:
- Experience with chromatin conformation capture techniques
- Bioinformatics expertise
- Experience with Nanopore sequencing
About the Institutions
The Faculty of Biology at Adam Mickiewicz University holds the highest A+ national research category in Poland and ranks among the country’s top institutions in Life Sciences.
IMBB is a dynamic international research institute hosting 21 independent research groups and approximately 160 researchers. Over the past decade, IMBB scientists have secured over 100 grants worth ~120 million PLN.
The Developmental Epigenetics Lab is affiliated with the Centre of Advanced Technologies (CAT AMU), a €63 million EU-funded interdisciplinary institute offering state-of-the-art research facilities including confocal microscopy, cell sorting, and animal facilities.
How to Apply
Interested candidates should submit the following documents as a single PDF file:
- Cover Letter
- Curriculum Vitae
- Contact details of three referees
Send applications to: michal.gdula@amu.edu.pl
📌 Please include the required GDPR consent statement in your application as specified in the official announcement.
Informal inquiries are welcome.
Important Dates
- Start Date: 1 May 2026
- Application Deadline: 20 March 2026
- Interviews: Shortly after deadline (likely the following week)
