Postdoctoral Training Fellow: The V Li Lab is seeking to recruit a highly motivated and ambitious Postdoctoral Training Fellow to join their research team for a fixed term of 4 years. The post-holder will be responsible for leading their own research projects, collaborating within the lab and externally, and guiding PhD students in their research. The research area is focused on investigating the molecular regulation of intestinal stem cell and cancer, with a focus on WNT signalling, using high-throughput multi-omics, “mini-guts” and transgenic mouse models.
Designation: Full-time, fixed term position on Crick terms and conditions of employment.
Research Area: Molecular regulation of intestinal stem cell and cancer
Location: The Francis Crick Institute, London, UK
Eligibility/Qualification: The post holder should have a PhD in Developmental Biology, Stem Cells, Cancer, Computational Biology or be in the final stages of PhD submission. They should also have good knowledge and experience in molecular biology, intestinal stem cell biology and cancer biology and/or computational biology.
Salary: From £41,935, subject to skills and experience.
Hours per week: 36 (full time)
Job Description: The post holder will be responsible for leading their own research projects and contributing to other projects on a collaborative basis (both in the lab and with external collaborators), supervising and providing technical advice to more junior members of the team when appropriate, and liaising with collaborators to perform shared experiments. The specific aims of the project include single-cell RNA/ATAC-seq prep and data analysis, integrative multi-omic analysis (including transcriptomics, metabolomics, proteomics and metagenomics), computational modelling of gene regulatory network, animal handling and endoscopic injection of organoids, generating and analyzing complex transgenic mouse models, 3D organoid culture derived from primary human and mouse intestine, and co-culture of organoids with stromal mesenchyme/lymphocytes.
How to Apply: Applicants should submit a CV, a covering letter describing their previous research experience and why they are interested in the position, and contact details for three referees. Applications should be submitted online before the closing date.
Closing date for Apply: 26 May 2023, 23:59 BST
Table:
| Job Reference | R1156 |
|---|---|
| Contact | Email administrator |
Key Experience and Competencies:
Essential:
- PhD in Developmental Biology, Stem Cells, Cancer, Computational Biology or in the final stages of PhD submission
- Good knowledge and experience in molecular biology, intestinal stem cell biology and cancer biology and/or computational biology
- Good computational/bioinformatic skill and/or mathematical modelling to address complex biological questions
- Experience in single-cell RNA/DNA-seq including data analysis
- Animal work experience
- Excellent track record of research as evidenced by publications in referred journals
- Strong written and oral communication skills as evidenced by data presentation at scientific meetings
- Ability to work independently as well as a good team player
Desirable:
- Experience in integrative multi-omic analysis
- Experience in creating or analyzing complex transgenic mouse models
- Experience in 3D organoid culture
- Experience in orthotopic intestinal tumor model in mice
- Experience in histology and confocal imaging
