Job Title: Functional and Pharmacological Characterization of Insect Inositol-1,4,5-triphosphate Receptors
Summary: The University of Cambridge’s Department of Pharmacology is offering a fully funded PhD Studentship focused on investigating insect inositol-1,4,5-triphosphate receptors (IP3Rs) as potential targets for insecticide development. The project involves multidisciplinary research encompassing molecular biology, bioinformatics, and electrophysiology.
| Designation | Research Area | Location |
|---|---|---|
| PhD Studentship | Functional and Pharmacological Characterization of Insect IP3Rs | University of Cambridge, UK |
Eligibility/Qualification: The successful candidate should have, or expect to have, an Honours Degree (or equivalent) with a minimum of 2.1 in Plant Science, Applied Statistics, or related science subjects. Candidates with an appropriate Masters degree are encouraged to apply. The opportunity is open to UK, EU, and international applicants. English language proficiency requirements apply.
Job Description: This four-year studentship aims to explore the potential of insect IP3Rs as novel insecticide targets. The research project is divided into several phases, including developing cell-based assays, pharmacological studies, screening compounds, and electrophysiological investigations. The Department of Pharmacology at the University of Cambridge offers extensive expertise in cellular calcium signaling.
How to Apply: Interested candidates are encouraged to contact Prof. Graham Ladds (Email: grl30@cam.ac.uk) for an informal discussion regarding the research content of this PhD. To apply, complete the online application form before the deadline of 7th January 2024. Interviews will be conducted in January 2024.
For detailed application instructions and further information, please visit the CTP-SAI website.
Last Date for Apply: 7th January 2024
Job Title: Mining the microbiome: how do gut microbes modulate visceral pain?
Summary: The University of Cambridge’s Department of Pharmacology, in collaboration with AstraZeneca, is offering a 4-year PhD Studentship focusing on investigating the role of the gut microbiome in modulating visceral pain. This project combines expertise in neuroscience, pharmacology, and microbiology.
| Designation | Research Area | Location |
|---|---|---|
| PhD Studentship | Mining the microbiome: how do gut microbes modulate visceral pain? | University of Cambridge and AstraZeneca, Cambridge, UK |
Eligibility/Qualification: Applicants should hold or expect to obtain a first or upper second-class degree in a relevant subject such as neuroscience, pharmacology, or biology. The opportunity is open to UK citizens or overseas students who meet UK residency requirements. Full funding covering maintenance fees and the University Composition Fee is provided.
Job Description: This project aims to investigate the cellular mechanisms by which human gut microbes modulate visceral pain. The research includes functional recordings from pain-sensing neurons, in vivo behavioral experiments, and multidisciplinary techniques such as cell culture, electrophysiology, and Ca2+-imaging.
How to Apply: Applications are accepted through the University Application Portal. For application details and requirements, please visit the University of Cambridge’s Graduate Admissions page. For inquiries, contact Prof. Ewan St. John Smith (es336@cam.ac.uk) or Dr. John Linley.
Last Date for Apply: 31st October 2023
Job Title: Artificial intelligence design of antibody modulators of GABA-A receptors
Summary: The University of Cambridge offers a BBSRC-DTP Targeted Studentship for a motivated PhD candidate to work on precision pharmacology in the central nervous system. This project focuses on using artificial intelligence to design antibody modulators of GABA-A receptors, aiming to create novel pharmacological tools for neuroscience research.
| Designation | Research Area | Location |
|---|---|---|
| PhD Studentship | Artificial intelligence design of antibody modulators of GABA-A receptors | University of Cambridge, UK |
Eligibility/Qualification: Applicants should have a strong academic background, and a relevant degree in chemistry, biology, or related fields. The opportunity is open to both UK and overseas students who meet residency requirements. Full funding is provided.
Job Description: This interdisciplinary project involves the development of AI-based antibody design strategies to target GABA-A receptor subtypes. The research combines computational engineering with biophysical techniques, electrophysiology, and cryo-electron microscopy. The student will contribute to creating novel pharmacological tools for neuroscience research.
How to Apply: Application details and the application process are expected to open in September 2023. For inquiries or further information, contact Dr. Pietro Sormanni (ps589@cam.ac.uk) or Dr. Paul Miller (pm676@cam.ac.uk).
Job Title: Targeting chronic pain using new pharmacological approaches against sodium channels
Summary: The University of Cambridge, in partnership with industry partner Metrion Biosciences, offers an MRC-DTP PhD Studentship focusing on novel pharmacological approaches to target voltage-gated sodium channels for the treatment of chronic pain.
| Designation | Research Area | Location |
|---|---|---|
| PhD Studentship | Targeting chronic pain using new pharmacological approaches against sodium channels | University of Cambridge and Metrion Biosciences, Cambridge, UK |
Eligibility/Qualification: Applicants should have a strong academic background in fields such as pharmacology, biochemistry, or related subjects. The studentship covers UK/overseas fees and provides a stipend with an industry supplement.
Job Description: This project focuses on developing novel pharmacological approaches to target voltage-gated sodium channels for chronic pain treatment. The research combines expertise in small molecules, toxins, antibodies, and bioluminescence resonance energy transfer (BRET) techniques.
How to Apply: The application process is expected to open in October 2023. For inquiries or further information, contact Dr. Paul Miller (pm676@cam.ac.uk).
Please check the MRC-DTP website for updates on the application process.
Note: These job posts have been provided for informational purposes. Applicants are advised to verify the details, eligibility criteria, and application procedures on the official websites of the respective institutions and projects before applying.
