PhD Position: DNA Transformations: Embark on a pioneering journey in drug discovery through DNA-encoded libraries (DELs) with our fully funded PhD studentship. Join our research team in developing innovative photocatalytic transformations on DNA, expanding the range of synthetic reactions for the creation of diverse compound libraries. This opportunity is a gateway to advancing drug discovery and personalized medicine.
Study Area: Chemistry, Biochemistry, Natural Sciences
Location: Lancaster University, United Kingdom
Eligibility/Qualification:
- Applicants should hold, or expect to receive, a 1st class or 2:1 UK Master’s or BSc degree (or equivalent) in Chemistry, Biochemistry, or Natural Sciences.
- Theoretical and practical skills commensurate with a science-based undergraduate degree are required.
- Candidates with a 2:2 may be considered with excellent research skills demonstrated in their application and references.
- Strong interest in synthetic and medicinal chemistry.
- Enthusiasm for working in a laboratory environment.
- Good written and oral communication skills.
Description: This PhD project focuses on overcoming limitations in DNA-encoded libraries by developing novel photocatalytic transformations on DNA. By expanding the range of synthetic reactions, the project aims to contribute to the creation of the next generation of diverse compound libraries. The successful candidate will play a pivotal role in groundbreaking research essential for advancing drug discovery and personalized medicine.
How to Apply:
- Download the Natural Sciences Funded PhD Application Form.
- Complete the Application Form, renaming the document with your ‘Name and Application Form’ (e.g., Joe Bloggs Application Form).
- Submit the completed Application Form and a CV to naturalsci@lancaster.ac.uk (Word or PDF files only).
- Rename the referee form with your ‘Name and Reference’ (e.g., Joe Bloggs Reference). Send the renamed reference form to two referees and request them to forward the document to naturalsci@lancaster.ac.uk (Word or PDF files only).
- You will receive a generic acknowledgment upon successfully sending the application documents.
Last Date:
- Deadline for applications: 15th March 2024
- Provisional Interview Date: Mar – April 2024
- Start Date: October 2024
Enquiries: Dr. Jamie Docherty welcomes informal email enquiries. Please contact Jamie at j.docherty2@lancaster.ac.uk for more information.
Studentship Funding: A tax-free stipend will be paid at the standard UKRI rate, currently £18,622. This is a fully funded studentship of 3.5 years for UK/Home students.
Further Reading:
- Peterson, A.A. & Liu, D.R. Small-molecule discovery through DNA-encoded libraries. Nat. Rev. Drug Discov. 22, 699–722 (2023).
- Li, L., Matsuo, B., Levitre, G., McClain, E.J., Voight, E.A., Crane, E.A. & Molander, G.A. Dearomative intermolecular [2 + 2] photocycloaddition for construction of C(sp3)-rich heterospirocycles on-DNA. Chem. Sci. 14, 2713-2720 (2023).
Application Process:
- Select the project you wish to apply for and make informal enquiries to the project supervisors if needed.
- Check the application deadline dates and eligibility criteria.
- Complete your application by following the links to the application form.
- After the closing date, shortlisted candidates will be invited for an interview, held in person, or by Skype or telephone.
- Successful candidates will be invited to apply via the admissions portal online. Please submit one application only and state the studentship you have applied for in the source of funding section.
- Once a formal offer is made, check the conditions in your offer letter and supply any outstanding documents by the required deadlines. If your offer is unconditional, this will not apply to you.
Please note: If English is not your first language, evidence of proficiency in English is required only after being offered a funded PhD and is not required as part of the initial application process. If you do not hear from us within four weeks of the closing date, consider your application unsuccessful.
