Summary
The University of Tübingen invites applications for a PhD position in Genome Engineering and Host-Pathogen Interactions within the Link Lab, part of the Cluster of Excellence “Controlling Microbes to Fight Infections” (CMFI). This position is available for a period of three years and will focus on identifying bacterial genes that control immune evasion in ESKAPE pathogens. The project uses CRISPR interference (CRISPRi) libraries and involves high-throughput immune assays and metabolomic profiling to discover novel therapeutic targets.
PhD Position in Genome Engineering and Host-Pathogen InteractionsUniversity of Tübingen, Germany
Designation
PhD Position – Genome Engineering and Host-Pathogen Interactions
Research Area
Microbiology, Immunology, Genome Engineering, Host-Pathogen Interactions, CRISPR Technology, Metabolomics
Location
University of Tübingen, Germany
Eligibility/Qualification
- Master’s degree in biotechnology, microbiology, molecular biology, or a related field.
- Background in microbial genetics, molecular biology, or infection biology.
- Experience with CRISPR-based methods, molecular cloning, or bacterial genetics is advantageous.
- Experience in metabolomics, mass spectrometry, or data analysis (e.g., Python, R) is a plus.
- Excellent communication skills in English (both written and spoken).
- Strong motivation to work at the interface of microbiology and immunology.
Job Description
The PhD project will focus on systematically identifying bacterial genes involved in immune evasion in ESKAPE pathogens using CRISPR interference (CRISPRi) libraries. The candidate will collaborate with the Mager Lab in immunology and will be responsible for constructing and screening CRISPRi libraries in E. coli and S. aureus, followed by metabolomic and chemical characterization of bacterial mutants. The research will include high-throughput dendritic cell reporter assays for immune activation. The position involves manuscript preparation for peer-reviewed journals, conference presentations, and active collaboration within an interdisciplinary team of microbiologists and immunologists.
How to Apply
- Send your application as a single PDF file to hannes.link@uni-tuebingen.de.
- The PDF should include a cover letter, CV, and relevant certificates.
Last Date for Apply
Applications will be reviewed starting from April 1st, 2026, and will continue until the position is filled.
The University of Tübingen encourages applications from equally qualified individuals with disabilities. Women and underrepresented groups in research are especially encouraged to apply. The university is committed to equal opportunity and diversity.
