PhD Scholarship: Bioinorganic Chemistry: The CNRS Coordination Chemistry Laboratory (LCC), Toulouse, in collaboration with the Institute of Cellular and Integrative Neurosciences, Strasbourg, invites applications for a fully funded 36-month PhD thesis supported by the Foundation “Vaincre Alzheimer”.
The project focuses on evaluating novel traceable copper ligands as a therapeutic strategy for Alzheimer’s disease, integrating chemistry, biology, and neuroscience.
PhD Scholarship: Bioinorganic Chemistry Approach to Alzheimer’s Disease(CNRS – Coordination Chemistry Laboratory, France)
Designation
PhD Research Scholar (Doctoral Candidate)
Research Area
- Alzheimer’s Disease
- Bioinorganic Chemistry
- Therapeutic Chemistry
- Amyloid Biology
- Metal Ion Homeostasis (Copper & Zinc)
- Cellular and Molecular Neuroscience
Location
- Primary Institution:
CNRS Coordination Chemistry Laboratory (LCC), Toulouse, France - Collaborating Institution:
Institute of Cellular and Integrative Neurosciences, Strasbourg, France
Eligibility / Qualification
- Master’s degree (or equivalent) in:
- Cellular Biology
- Molecular Biology
- Biochemistry
- Pharmacology
- Related life-science disciplines
- Strong motivation to work at the chemistry–biology–health interface
- Interest in therapeutic chemistry and multidisciplinary research
- Perseverant, curious, and highly motivated research attitude
Job Description
The PhD project aims to evaluate novel copper-chelating ligands synthesized at LCC for their therapeutic potential against Alzheimer’s disease.
Key responsibilities include:
- In vitro evaluation of copper-ligand interactions with Aβ peptides
- Cell-based studies to analyze:
- Cellular uptake of ligands
- Copper redistribution
- Cell viability and inflammatory markers
- Investigation of oxidative stress and ROS production
- Monitoring ligands in living cells using time-resolved confocal microscopy
- Working in a multidisciplinary environment across chemistry, biology, and neuroscience
Supervision & Research Environment
- Primary Supervisors (Toulouse – LCC):
- Dr. Charlène Esmieu
- Dr. Christelle Hureau
- Collaborating Supervisor (Strasbourg):
- Dr. Nicolas Vitale
- Research Team:
Team F “Alzheimer, Amyloids and BioInorganic Chemistry”
How to Apply
Interested candidates should submit:
- A brief Curriculum Vitae (CV) including career history
- Cover letter describing motivation and research interest
- Most recent academic results/transcripts
- Two academic or professional references
Applications should be sent to:
Charlène Esmieu
📧 Email: charlene.esmieu@lcc-toulouse.fr
📞 Phone: +33 5 61 33 31 20
Funding & Duration
- Funding Agency: Foundation “Vaincre Alzheimer”
- Duration: 36 months
- Start Date: 1st July 2026
Last Date for Apply
Until position filled
