Summary:
This PhD project seeks a motivated candidate to develop novel computational frameworks for understanding mechano-driven cartilage tissue engineering. The research will focus on creating computational growth and remodeling (G&R) models to elucidate how cartilage microtissue growth dynamics, matrix composition, and anisotropic matrix architecture are influenced by their mechanical and geometric environments. This work aims to provide crucial mechanistic insights, inform in vitro experiments, and contribute to the design of advanced biomaterials and tissue engineering strategies for cartilage regeneration.
PhD Scholarship: Computational Growth and Remodeling of Cartilage Microtissues
Designation:
PhD Candidate / Scientific Staff
Scholarship Details:
- Salary: € 3.204 – € 4.051 gross per month
- Full-time Equivalent: 1.0 FTE
Research Area:
Computational growth and remodeling of cartilage microtissues, Tissue Engineering, Mechanobiology, Regenerative Medicine, Finite Element Modeling.
Location:
Eindhoven University of Technology (TU/e), Department of Biomedical Engineering, Brainport Eindhoven region, Netherlands.
Eligibility/Qualification:
- MSc degree (or equivalent) in Biomedical Engineering, Mechanical Engineering, Applied Mathematics, or a related engineering/scientific field.
- Essential: Demonstrated experience with finite element modeling.
- Strong affinity for complex theoretical concepts in mechanics and/or applied mathematics.
- A research-oriented attitude, a strong drive to learn, and the ability to take initiative and be creative.
- Experience with homogenized constrained-mixture models or other tissue growth models, and experience with mechanical characterization of biological materials are considered a plus.
- Ability to work collaboratively in interdisciplinary teams.
- Excellent communication skills, fluent in spoken and written English.
Job Description:
The successful candidate will develop and extend in-house homogenized constrained-mixture (finite element) models to simulate cartilage growth and remodeling (G&R). This will involve simulating cartilage microtissues growing within engineered, confining microenvironments to investigate key parameters influencing growth processes, with a primary focus on anisotropic matrix organization. The role requires close collaboration with experimental researchers to tune and validate computational models and to inform new in vitro experiments. The PhD candidate will be an integral part of the Orthopaedic Biomechanics (OPB) and Modeling in Mechanobiology (MMB) groups within the Department of Biomedical Engineering at TU/e. Responsibilities include contributing to teaching activities, supervising BSc and MSc students, presenting research at international conferences, publishing in scientific journals, and completing a doctoral dissertation.
How to Apply:
Applications should be submitted electronically via the university’s “apply button” (not by email or post). A complete application must include:
- A Cover letter detailing motivation and qualifications for the position.
- A Curriculum Vitae, including a list of publications (if applicable) and contact information for at least two references.
- A transcript of MSc course grades.
Incomplete applications may not be considered.
Last Date for Apply:
16-09-2026
