Postdoc Position in RNA-Based Therapeutics: The Interdisciplinary Nanoscience Center (iNANO), Aarhus University, invites applications for a 1-year postdoc position (with the potential for an extension). The position focuses on developing RNA-based therapeutics for targeting and inhibiting viruses, specifically Influenza A, using advanced biophysical and structural biology techniques. The chosen candidate will work in a highly collaborative and interdisciplinary environment.
Postdoc Position in RNA-Based Therapeutics for Viral Targeting
Designation
Postdoctoral Researcher
Department: Interdisciplinary Nanoscience Center (iNANO), Aarhus University
Details Overview
| Category | Details |
|---|---|
| Position | Postdoc in RNA-Based Therapeutics for Viral Targeting |
| Duration | 1 year (with the possibility of extension) |
| Expected Start Date | July 1, 2025 or as soon as possible thereafter |
| Application Deadline | April 18, 2025 (23:59 CEST) |
| Workplace | Interdisciplinary Nanoscience Center (iNANO), Gustav Wieds Vej 14, 8000 Aarhus, Denmark |
| Salary | Based on seniority and as per the Danish Ministry of Taxation and the Confederation of Professional Associations |
| Contact Persons | Assistant Prof. Julián Valero (jvalero@inano.au.dk) Prof. Jørgen Kjems (jk@mbg.au.dk) |
Research Area
The project focuses on the development of chemically modified RNA therapeutics targeting Influenza A virus utilizing in vitro selection (SELEX) techniques. It includes evaluating binding and viral inhibition using biophysical techniques (such as SPR and BLI), performing cell-based assays, and determining structural complexes using cryo-EM in collaboration with structural biology experts.
Location
The position will be based at the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.
Eligibility/Qualification
- PhD in Molecular Biology, Biochemistry, Nanoscience, Nanotechnology, or Medicinal Chemistry.
- Required Experience: Hands-on experience with RNA and/or nucleic acid nanotechnology.
- Preferable Skills:
- Aptamer selection and Next-Generation Sequencing (NGS).
- Bioconjugation strategies and binding/cell assays.
- Experience with cryo-EM structural determination and bioinformatics pipelines is advantageous.
- Must be socially oriented, self-driven, and able to work both independently and within an international collaborative team.
- Proficiency in written and spoken English is mandatory.
Job Description
The recruited postdoc will contribute to an international and interdisciplinary project focused on:
- Developing RNA-based therapeutics using chemically modified RNAs through SELEX methods.
- Evaluating binding affinity and viral inhibition via biophysical tools like SPR (Surface Plasmon Resonance) or BLI (Biolayer Interferometry).
- Performing cell-based assays and collaborating with structural biologists to utilize cryo-Electron Microscopy (cryo-EM) for determining RNA-protein complexes.
- Collaborating within a vibrant interdisciplinary team comprising chemical biologists, virologists, and other researchers.
Benefits
Aarhus University and iNANO provide:
- Access to state-of-the-art laboratory and research infrastructure, including shared equipment and clean-room facilities.
- A dynamic, interdisciplinary, and highly collaborative research environment.
- Opportunities for national and international collaborations.
- A workplace with emphasis on equality, professionalism, and a healthy work-life balance.
How to Apply
Applications must be submitted via the Aarhus University’s recruitment system, referenced under the job advertisement on their website.
The application must include:
- CV including educational background and work experience.
- A degree certificate.
- A complete list of publications.
- A statement of future research plans and past research activity.
- Information on teaching experience (if applicable).
- Verified information on previous teaching activities.
Letters of reference can be uploaded directly by referees if agreed beforehand. Instructions for this will be provided during the application process.
Deadline for Applications
April 18, 2025 (23:59 CEST)
Applications received later than the deadline, including letters of reference, cannot be considered.
Become a part of a stimulating and innovative research environment at iNANO, Aarhus University, and contribute to cutting-edge advancements in RNA therapeutics and viral biology. For further information, reach out to Assistant Prof. Julián Valero or Prof. Jørgen Kjems through the provided contact details.
