Postdoctoral Fellow – Nile Lab: Calico Life Sciences LLC** invites applications for a Postdoctoral Fellow position in the Nile Lab focused on Ubiquitin/UBL Chemical Biology.** This is a unique opportunity for ambitious early-career scientists to conduct innovative, high-impact research in aging biology within a collaborative and multidisciplinary environment.
The fellowship is a fixed-term educational appointment of three years (with potential extension to a fourth year) and is designed to develop fellows into independent investigators in academia or industry.
Postdoctoral Fellow – Nile Lab (Ubiquitin/UBL Chemical Biology) Calico Life Sciences LLC | South San Francisco, CA
📋 Summary Table
| Field | Details |
|---|---|
| Organization | Calico (Calico Life Sciences LLC) |
| Program | Calico Postdoctoral Fellowship Program |
| Lab | Nile Lab |
| Designation | Postdoctoral Fellow |
| Research Focus | Ubiquitin/UBL Chemical Biology |
| Location | South San Francisco, CA (Onsite) |
| Duration | 3 years (possible 4th year extension) |
| Salary | Estimated base salary: $95,000 |
| Start Date | Rolling start dates |
| Work Mode | Onsite (5 days/week) |
Designation
Postdoctoral Fellow – Nile Lab (Ubiquitin/UBL Chemical Biology)
Research Area
- Ubiquitin and UBL signaling mechanisms
- E3 ubiquitin ligases and substrate recognition
- Chemical biology approaches to redirect E3-ligase activity
- Protein biochemistry and mechanistic enzymology
- Structural biology and biophysical methods
- Directed evolution and selection technologies
- Aging biology and age-related disease mechanisms
The Nile Lab focuses on understanding the biochemical and biophysical principles governing ubiquitin signaling and translating these insights into systematic chemical biology strategies.
Location
South San Francisco, California, United States
(Onsite position – five days per week)
Eligibility / Qualification
Education
- Recently completed PhD in a relevant scientific or computational field
- Current PhD students within 12 months of completion may apply
- Applicants must have completed their PhD within the past 3 years
- Must not have completed postdoctoral training at more than one other lab/company
Experience
- Demonstrated significant scientific contributions
- Preferably at least one meaningful first-author publication accepted
Skills & Competencies
- Strong foundation in core scientific methodologies
- Quantitative analytical and problem-solving skills
- Excellent communication and teamwork abilities
- Detail-oriented and highly organized
- Adaptable and able to manage shifting priorities
- Comfortable tackling complex scientific problems
- Willingness to work onsite full-time
Job Description / Responsibilities
- Lead Independent Research: Develop and execute innovative research projects with dedicated resources, including high-risk/high-reward studies
- Advance Aging Research: Contribute to Calico’s mission of understanding aging and age-related diseases
- Execute & Analyze Experiments: Conduct rigorous experiments, perform computational/quantitative analysis, and troubleshoot procedures
- Publish Scientific Work: Generate publishable research and submit in a timely manner
- Collaborate Across Teams: Present findings to computational scientists, lab scientists, and engineers
- Professional Development: Participate in mentorship, annual reviews, career coaching, Postdoc Summit, workshops, and leadership sessions
About the Nile Lab
The Nile Lab investigates how E3 ubiquitin ligases recognize, modify, and regulate substrates. Research emphasizes:
- Rigorous protein purification
- Quantitative mechanistic studies
- Reconstitution of multi-component systems in vitro
- Structural and chemical biology
- Advanced imaging and biophysical tools
Recent group publications include work in leading journals such as Nature Communications, JACS, and Chemical Sciences.
How to Apply
Applicants must submit the following:
- Research Proposal (1–2 pages) – Proposed investigation in the Nile Lab
- Updated CV – Including full publication list
- Cover Letter
- List of 2–3 References – Including PhD advisor (and postdoctoral advisor if applicable)
Additional Information Required:
- Work authorization status in the U.S.
- Visa sponsorship requirement (if applicable)
- Education details
- Completion of voluntary self-identification forms
Applications are submitted online via Calico’s official career portal.
Last Date to Apply
Applications are reviewed on a rolling basis. Early application is encouraged.
