Postdoctoral Fellow – Therapeutics: AstraZeneca is seeking a highly motivated Postdoctoral Fellow to join our Cardiovascular Renal & Metabolism (CVRM) and Discovery Sciences (DS) departments. This role involves pioneering research in developing next-generation oligonucleotide therapeutics with enhanced efficacy and tissue selectivity. If you are passionate about scientific innovation and eager to make a meaningful impact in drug discovery, we welcome your application.
Postdoctoral Fellow – Development of Next Generation Oligonucleotide Therapeutics
Designation
Postdoctoral Fellow
Research Area
Oligonucleotide Therapeutics, Synthetic Chemistry, Drug Discovery
Location
Gothenburg, Västra Götaland County, Sweden
Eligibility/Qualification
- Essential Requirements:
- PhD degree (or equivalent) in synthetic chemistry, chemical biology, biochemistry, or a related field.
- Proficiency in organic chemistry and/or conjugation chemistry.
- Desirable Requirements:
- Experience with oligonucleotide and/or peptide chemistry.
- Familiarity with biophysical, biochemical, and/or cellular experiments.
- Excellent written and oral communication skills.
- Strong planning, organizational, and time management skills.
- Ability to work effectively in a multidisciplinary research environment.
Job Description
As a Postdoctoral Fellow, you will:
- Design, generate, and profile innovative oligonucleotide conjugates aimed at improving efficacy and tissue selectivity by integrating plasma half-life extension motifs.
- Lead and drive the project under the supervision of a cross-functional AstraZeneca team, collaborating closely with an academic expert.
- Conduct groundbreaking research using state-of-the-art oligonucleotide synthesis facilities to develop hypothesis-driven siRNA conjugates.
- Develop competencies in a range of in vitro assays, including biophysical, biochemical, and cellular experiments, to profile the generated conjugates.
- Select conjugates for in vivo studies (PKPD) and support the corresponding analyses.
- Contribute to planning, writing, publishing, and presenting high-quality scientific papers.
This position is part of a three-year program, consisting of an initial two-year period with a potential merit-based extension of one year.
How to Apply
Interested candidates are encouraged to apply via our official AstraZeneca careers page. Please include your CV, a cover letter detailing your research experience, and contact information for at least two references.
Last Date for Apply
Applications will be accepted from January 2, 2025, until January 31, 2025. We encourage early applications as we reserve the right to close the vacancy earlier if suitable candidates are found.
Join us at AstraZeneca to contribute to innovative research and make a direct impact on patients’ lives through transformative medicines!
