Postdoctoral in Molecular Biology & Biophysics: Join the Hospenthal Group at the Institute of Molecular Biology & Biophysics (IMBB) at ETH Zurich to explore the molecular mechanisms behind natural transformation in bacteria, a pivotal process in horizontal gene transfer. We are searching for an enthusiastic and highly motivated postdoc to contribute to our multidisciplinary research team.
Postdoctoral Position in Molecular Biology & Biophysics – Hospenthal Group
Designation: Postdoctoral Researcher
Research Area: Molecular Biology, Biophysics, Horizontal Gene Transfer
Location: ETH Zurich, Hönggerberg Campus, Zurich, Switzerland
Eligibility/Qualification:
- PhD Degree: In biochemistry, molecular biology, structural biology, or a related field.
- Skills & Experience:
- Strong background in horizontal gene transfer, natural transformation, membrane proteins, and DNA transporters.
- Proficiency in protein expression and purification.
- Experience with quantitative biophysical methods (e.g., fluorescence anisotropy, ITC, SPR).
- Familiarity with cryo-EM workflow (including sample/grid preparation, data acquisition, processing, and model building).
- Demonstrated ability to write scientific papers and engage actively in discussions.
- Language Proficiency: Strong English skills required (both spoken and written).
- Personal Skills: Proactivity, adaptability, and capability of working both independently and collaboratively.
Job Description:
You will investigate how DNA is translocated from the extracellular environment into the bacterial cytoplasm, integrating it into the genome. Responsibilities include:
- Expressing and purifying proteins.
- Conducting quantitative binding experiments for protein-protein and protein-DNA interactions.
- Producing stable complexes between proteins and/or DNA.
- Determining structures of proteins/complexes.
- Designing mutants and conducting in vivo experiments.
- Performing functional assays using microbiological approaches and fluorescence microscopy.
How to Apply:
Please submit your application online, including:
- A cover/motivation letter demonstrating your suitability for the position and addressing your past research and future research plans at ETH.
- A complete curriculum vitae including your academic record.
- A copy of your PhD degree.
- The name and contact information for two references.
Note: Applications sent via email or postal services will not be considered.
Last Date to Apply:
Evaluation of applications will begin immediately and will continue until a suitable candidate is identified.
For more information, contact Prof. Dr. Manuela Hospenthal at manuela.hospenthal@mol.biol.ethz.ch (no application documents).
