Postdoctoral in Super-Resolution Microscopy: The University of Cambridge invites applications for a Postdoctoral Research Associate position to explore extracellular interactions in T-cell signaling. This role will utilize advanced single-molecule imaging and super-resolution microscopy techniques.
Postdoctoral Research Associate in Single-Molecule Imaging and Super-Resolution Microscopy
Designation:
Postdoctoral Research Associate
Research Area:
Biophysics, Immunology, Optical Microscopy
Location:
Yusuf Hamied Department of Chemistry, University of Cambridge
Eligibility/Qualification:
- A PhD (or close to completion) in chemistry, physics, biophysics, optical engineering, or a related discipline.
- Strong background in optical microscopy, single-molecule imaging, and/or super-resolution techniques (e.g., STORM, PAINT, MINFLUX, or lattice light-sheet microscopy).
- Experience in instrument development, including custom optics and hardware automation.
- Proficiency in programming (Python, MATLAB) for image processing and data analysis.
- Excellent teamwork and communication skills, with a commitment to interdisciplinary research.
Job Description:
The successful candidate will:
- Develop and implement next-generation 3D super-resolution microscopy techniques to visualize and characterize close contacts in T-cell signaling.
- Engineer advanced optical microscopy tools to map the nanoscale distribution of TCRs, coreceptors, and immune checkpoints on T cells.
- Apply high-speed, high-density 3D single-molecule super-resolution imaging to study spatial organization of immune receptors.
- Collaborate with biophysicists and immunologists at the University of Oxford, integrating imaging data with computational models of receptor signaling and T-cell activation.
How to Apply:
Interested candidates should click the ‘Apply’ button on the University of Cambridge recruitment system to register and complete their application online. For informal inquiries, contact Prof. Steven Lee at sl591@cam.ac.uk or Prof. Klenerman at dk10012@cam.ac.uk. Please quote reference MA46951 in your application.
Last Date to Apply:
10 September 2025
This position is an exciting opportunity to work at the interface of instrument development, super-resolution imaging, and immune cell biology.
