Summary
The Leiden Institute of Chemistry is seeking a talented Postdoctoral Research Scientist to lead the development of covalent small molecule inhibitors for emerging cancer targets. This project focuses on optimizing lead compounds identified through chemical proteomics and developing bifunctional analogues to induce protein degradation.
Job Details
| Designation | Postdoctoral Research Scientist |
| Research Area | Synthetic/Medicinal Chemistry, Chemical Proteomics, and Chemical Biology |
| Location | Leiden, Netherlands (Leiden Bioscience Park) |
| Last Date for Apply | 20 November 2026 |
| Apply Link | Apply Here |
Job Description
The postdoctoral researcher will lead the design and synthesis of electrophilic small molecules, evaluate their selectivity using chemoproteomics, and perform preliminary functional characterization in cell-based or biochemical assays. Key responsibilities include:
- Design, synthesis, and characterization of covalent small molecules.
- Research reporting in group/department meetings, conferences, and publications.
- Teamwork and supervision, integrating with lab members leading biological studies.
- Developing chemical tools to validate novel cancer targets.
Eligibility/Qualification
Essential Skills
- Proficient synthetic/medicinal chemist capable of designing and troubleshooting synthetic routes.
- Demonstrated ability to write and present research in English (publications, theses, or presentations).
- Commitment to rigorous scientific standards, accurate record keeping, and data management.
- Ability to work independently and manage time effectively.
Preferred/Optional Skills
- Prior experience in enantioselective synthesis and covalent/electrophilic functional groups.
- Experience in small molecule drug development, SAR studies, and physicochemical property optimization.
- Experience in functional characterization of inhibitors in cell-based, biochemical, or biophysical assays.
What We Offer
- A monthly salary between €3,706 and €5,760 gross (based on a full-time appointment of 38 hours).
- An initial 6-month contract with the possibility of extension based on funding and performance.
- 8% holiday allowance and an 8.3% end-of-year bonus.
- Full reimbursement of public transport commuting costs.
- Flexible working hours and hybrid working options within the Netherlands.
How to Apply
To apply, please click the application button on the official university careers portal. Your application must include the following documents:
- A short motivation letter clearly indicating WHY you are applying for this specific position and WHAT makes you a suitable candidate.
- A detailed CV including the title and date of your PhD, the name of your PhD supervisor, and details of any prior postdoctoral/research positions.
- At least two letters of reference from your current and/or prior managers.
Note: Applications not meeting these specific requirements will not be assessed or receive a response.
Contact Information
For questions regarding the procedure, contact Pauline Hoftijzer at p.hoftijzer@lic.leidenuniv.nl. For project-specific inquiries, contact Dr. Madeline E. Kavanagh at m.e.kavanagh@lic.leidenuniv.nl.
