🧬 Postdoctoral Researcher – Developmental Biology & Genome Editing
Location: Philadelphia, PA, USA
Lab: Modzelewski Lab (The Modz Lab), Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania
Principal Investigator: Dr. Andrew Modzelewski
Funding: NIH-NIGMS, Beckman, Searle, and Packard Foundations
Application Deadline: Rolling until filled
Postdoctoral Researcher – Developmental Biology & Genome Editing
Postdoctoral Researcher – Developmental Biology
The Modzelewski Lab at the University of Pennsylvania is seeking highly motivated postdoctoral researchers to explore the role of retrotransposons in mammalian development, fertility, and disease. Our research integrates developmental biology, genome editing, and bioinformatics to investigate how retrotransposon reactivation influences gene regulation during preimplantation development and contributes to conditions such as infertility, aging, and cancer. We employ innovative tools like CRISPR-EZ, an electroporation-based genome editing technique, to facilitate our studies.
📋 Position Overview
| Title | Postdoctoral Researcher – Developmental Biology & Genome Editing |
|---|---|
| Designation | Postdoctoral Researcher |
| Research Area | Retrotransposons, Developmental Biology, Genome Editing |
| Location | Philadelphia, PA, USA |
| Eligibility/Qualification | Ph.D. in Biological Sciences or related fields |
| Application Deadline | Rolling until filled |
🧪 Research Focus
- Retrotransposon Reactivation: Investigate the regulatory roles of retrotransposons during early embryonic development and their impact on gene expression.
- Chimeric Transcripts: Study the formation of novel promoters and exons resulting from retrotransposon integration and their functional consequences.
- CRISPR-EZ Technology: Utilize and further develop the CRISPR-EZ method for efficient genome editing in zygotes across various species.
- Comparative Biology: Conduct cross-species analyses to understand conserved mechanisms of retrotransposon function.
- Disease Modeling: Explore the implications of retrotransposon activity in aging, infertility, and cancer through in vivo models.
🎯 Qualifications
- Ph.D. in Biological Sciences, Biochemistry, Bioengineering, Biostatistics, or related fields.
- Experience in developmental biology, non-coding RNAs, stem cell research, genome editing, or bioinformatics is highly desirable.
- Strong motivation and passion for research in biology, reproduction, development, and disease mechanisms.
- Previous experience with mouse models and embryo manipulation is advantageous but not mandatory.
📝 Application Process
Required Documents:
- Curriculum Vitae (CV) or NIH Biosketch
- Cover Letter detailing research interests and relevant experience
- Contact information for 2–3 references
Submission:
Please send all application materials directly to Dr. Andrew Modzelewski at amodz@upenn.edu.(bgscareerdevelopment.com)
🌐 About the Modzelewski Lab
Located within the University of Pennsylvania’s School of Veterinary Medicine, the Modzelewski Lab focuses on understanding the functional roles of retrotransposons in development and disease. By integrating cutting-edge genome editing technologies with developmental biology, the lab aims to uncover novel regulatory mechanisms and their implications for human health. For more information, visit www.themodzlab.org.
