Postdoctoral Researcher in Cryo-EM and Cryo-ET: The Paulino Lab is seeking two highly motivated and versatile postdoctoral researchers with extensive experience in cryo-EM and/or cryo-ET. The successful candidates will join a collaborative and cutting-edge research environment in Heidelberg, Germany. The positions involve participation in two distinct projects: a collaborative cryo-EM/cryo-ET platform and cryo-ET studies on presynaptic active zones.
Designation:
Postdoctoral Researcher
Research Area:
Cryo-Electron Microscopy (Cryo-EM) and Cryo-Electron Tomography (Cryo-ET)
Location:
Heidelberg University Biochemistry Center (BZH), Heidelberg, Germany
Eligibility/Qualification:
- Ph.D. in a relevant field.
- Extensive experience in cryo-EM of biological samples.
- Proficiency in sample preparation, operation of high-end microscopes, data collection, and image processing for single particle analysis and/or cryo-electron tomography.
- Experience in cryo-FIB/SEM or CLEM is beneficial but not required.
- A strong interest in method optimization/development.
- Excellent organizational, interpersonal, and scientific communication skills.
Job Description:
Project 1: Collaborative Cryo-EM/Cryo-ET Platform
The postdoctoral researcher will join the technology platform of the newly granted German Collaborative Research Center SFB/CRC 1638, titled ‘Cellular Remodeling – How Changing Form Creates Function.’ The candidate will collaborate with several research groups within Heidelberg University, EMBL, Max-Planck Institute, the German Cancer Research Center (DKFZ), the Heidelberg Medical Faculty, and the University of Mannheim. The role involves enabling cryo-EM SPA and cryo-ET methodologies to support various projects within the CRC, with a specific focus on membrane biology.
- Application Deadline: October 1, 2024
- Earliest Start Date: November 1, 2024 (Flexible)
Project 2: Cryo-ET on Presynaptic Active Zone
The postdoctoral researcher will participate in the transregional collaborative research center TRR/CRC 186 on ‘Molecular Switches in the Spatio-Temporal Control of Cellular Signal Transmission.’ This project involves collaboration with the group of Stephan Sigrist from the Free University of Berlin, aiming to combine super-resolution microscopy with cryo-ET data to study the presynaptic active zone scaffold architecture.
- Application Deadline: November 1, 2024
- Earliest Start Date: December 1, 2024 (Flexible)
Offer:
- Initial contract: Full-time for two years, with the possibility of extension.
- Salary: According to the E13 German public pay scale, including several social benefits.
- Location: Based at the Heidelberg University Biochemistry Center (BZH) and integrated within the HdcryoNet cryo-EM network.
Work Environment:
The Paulino Lab fosters a motivating and supportive atmosphere with a focus on scientific discovery. The lab is committed to mentoring and career development, offering access to various career development programs like heiTRACKS. Heidelberg offers a vibrant international and intellectual community, set within a picturesque historic city known for its high quality of life.
How to Apply:
Interested candidates should submit the following documents:
- Cover letter, including a summary of research experience and suitability for the position.
- Curriculum Vitae (CV).
- Contact details of two referees.
Submission:
Send the application materials to cristina.paulino@bzh.uni-heidelberg.de.
Last Date to Apply:
- Project 1: October 1, 2024
- Project 2: November 1, 2024
