Summary
The Pasque Lab at KU Leuven is seeking a highly motivated Postdoctoral Researcher to join an interdisciplinary research project dedicated to decoding early human post-implantation development and pluripotency. Utilizing stem cell–based embryo models (such as blastoids), single-cell multi-omics, CRISPR perturbations, and high-resolution microscopy, the researcher will investigate cell fate decisions, epigenetic mechanisms (including X-chromosome inactivation), and gene regulatory networks. The project is conducted in close collaboration with leading international institutions, including the Curie Institute and the University of Nantes.
Postdoctoral Researcher in Stem Cell Biology and Early Human Development
Designation
Postdoctoral Researcher
Quick Overview
| Detail | Information |
| Job Title | Postdoctoral Researcher in Stem Cell Biology and Early Human Development |
| Reference Code | BAP-2026-546 |
| Employer / Institution | KU Leuven (Faculty of Medicine, Department of Development and Regeneration) |
| Location | Leuven, Belgium |
| Employment Type | Full-time (Voltijds) |
| Contract Duration | Initial 1-year appointment, extendable up to 3 years |
| Application Deadline | September 30, 2026 (23:59 CET) |
| Primary Contact | Prof. Vincent Pasque (vincent.pasque@kuleuven.be) |
Research Area
- Stem Cell Biology & Human Pluripotent Stem Cells
- Early Human / Mammalian Embryonic Development & Peri-implantation
- Epigenetics & X-Chromosome Inactivation
- Single-Cell (Multi)Omics & Transcriptomics
- Stem Cell-Based Embryo Models (Blastoids) & Cell Fate Specification
Location
Leuven, Flanders, Belgium
(Faculty of Medicine, Department of Development and Regeneration / Leuven Single-Cell Omics Institute)
Eligibility / Qualification
- Education: Ph.D. in Life Sciences, Stem Cell Biology, Developmental Biology, Molecular Biology, or a closely related discipline.
- Track Record: Strong publication record in peer-reviewed international scientific journals.
- Core Expertise: Demonstrated hands-on experience in mammalian stem cells, gene regulation, and molecular biology techniques.
- Advantageous Skills / Prior Experience:
- Mammalian cell culture & human pluripotent stem cells (hPSCs)
- Stem cell-based embryo models & early mammalian embryogenesis
- Epigenetics and X-chromosome inactivation
- High-resolution microscopy and RNA FISH
- Single-cell genomics / transcriptomics / multi-omics and computational biology
- Soft Skills: High enthusiasm for collaborative, interdisciplinary research and strong communication abilities.
Job Description & Responsibilities
Project Background
The researcher will be embedded in the Pasque lab (affiliated with the Leuven Single-Cell Omics Institute) and collaborate closely with external teams led by Dr. Claire Rougeulle (Curie Institute, France), Dr. Laurent David (University of Nantes, France), and Dr. Thierry Voet (KU Leuven). The project aims to unravel the gene regulatory networks underlying cell fate specification in extraembryonic lineages and epigenetic dynamics during early human post-implantation stages.
Key Responsibilities:
- Develop, culture, and manipulate stem cell-based embryo models to investigate cell fate transitions and epigenetic processes (e.g., X-chromosome inactivation).
- Generate, process, and analyze microscopy data and single-cell (multi)omics datasets.
- Work collaboratively within an international, interdisciplinary team comprising specialists in epigenetics, computational biology, and embryology.
- Actively engage in career development, scientific publication, grant writing, leadership training, and research presentations.
What KU Leuven Offers
- Competitive salary based on KU Leuven academic pay scales.
- Initial 1-year contract with extension up to 3 years subject to performance and available funding.
- Access to world-class core facilities and cutting-edge single-cell omics/imaging technologies.
- A supportive, international, and innovative research environment in a historic European university city.
How to Apply
Interested applicants must apply through the KU Leuven Online Application Tool and submit the following documents:
- Cover Letter detailing research interests, motivation, and relevant technical expertise.
- Curriculum Vitae (CV) including a full list of scientific publications.
- Contact Information for 3 professional referees.
- Application Portal: KU Leuven Online Application
- Vacancy Inquiries: Prof. Vincent Pasque via email at
vincent.pasque@kuleuven.be
Last Date to Apply
September 30, 2026 (23:59 CET)
