Applications are invited for a postdoctoral position as a Research Associate/Fellow in RNA Biology within Catherine Jopling’s research group at the University of Nottingham. This full-time, fixed-term position is funded by a BBSRC grant focused on mRNA targeting and post-transcriptional gene regulation, held jointly with the CRUK Scotland Institute.
Overview
| Designation | Research Associate/Fellow |
| Research Area | RNA Biology / Gene Regulation / Molecular Biology |
| Location | Biodiscovery Institute, University Park Campus, University of Nottingham, UK |
| Salary | £32,080 to £47,389 per annum (minimum £35,608 with relevant PhD) |
| Duration | Fixed-term for 36 months (flexible working options available) |
| Last Date for Apply | Sunday 15 November 2026 |
Job Description
The successful applicant will investigate the fundamental molecular mechanisms by which the CCR4-NOT deadenylase complex, non-canonical poly(A) polymerases (TENT4/5), and microRNAs coordinate mRNA localization to, and metabolism at, the endoplasmic reticulum. This research has significant implications for understanding core gene regulatory pathways and informing future mRNA therapeutics.
Key responsibilities include:
- Designing, executing, and optimizing molecular and cell biology experiments to achieve project objectives.
- Employing modern genomic techniques such as CRISPR/Cas9 genome modification, targeted protein degradation, and reporter assays.
- Conducting next-generation sequencing approaches including SLAMseq and nanopore sequencing.
- Collaborating closely with a companion postdoctoral fellow in Martin Bushell’s lab at the CRUK Scotland Institute, including reciprocal laboratory visits.
- Analyzing, preparing, and presenting data at group meetings, conferences, and for scientific publication.
Eligibility & Qualifications
- A PhD (or about to complete) in Molecular Biology, Biochemistry, Cell Biology, or a related discipline.
- Essential expertise in molecular biology techniques and mammalian cell culture.
- Proven ability or motivation to work with CRISPR/Cas9 genome modification and advanced RNA technologies.
- Bioinformatic analysis skills for RNAseq data are highly advantageous.
- Strong problem-solving ability, excellent written and verbal communication skills, and a commitment to working collaboratively in a team environment.
How to Apply
Interested candidates must submit their application through the University of Nottingham’s online recruitment portal.
For informal enquiries regarding the post, please contact Dr. Catherine Jopling via email at Catherine.jopling@nottingham.ac.uk. Please note that applications submitted directly via email will not be accepted.
