Research Associate in Circadian Biology: The Brancaccio Lab at the UK Dementia Research Institute (UK DRI) at Imperial College London is seeking a motivated and talented postdoctoral researcher to join their team. The project aims to develop new molecular tools for modifying circadian pathways to prevent or delay the onset of Alzheimer’s disease.
Designation
Research Associate
Research Area
Circadian biology, Alzheimer’s disease, molecular and cellular neuroscience
Location
Hammersmith Campus, London (Hybrid work model)
Eligibility/Qualification
- You will hold (or be near completion of) a PhD in neuroscience or a related discipline.
- Experience with laboratory techniques such as live imaging microscopy, advanced molecular biology (e.g., cloning, viral vector design, CRISPR/Cas9), and proficiency in data analysis software (MATLAB, ImageJ, R, etc.).
- Practical experience with techniques like RNAseq, RNA scope, and spatial transcriptomics is highly desirable.
- Knowledge of circadian biology is preferred but not strictly necessary.
Job Description
In this project, you will:
- Perform viral delivery of gene therapy vectors to modify circadian pathways.
- Conduct behavioral assessment of sleep-wake cycles and cognition in Alzheimer’s disease models.
- Utilize multiplexed live imaging in brain tissue and combinatorial intersectional genetics.
- Carry out multivariate statistical analysis of time series data to validate new chronotherapeutic interventions.
- Collaborate with a multidisciplinary team of researchers within the UK DRI at Imperial.
How to Apply
Please apply online through the Imperial College London career portal. The application should include your CV, a cover letter detailing your relevant experience and research interests, and the contact information of two referees.
Last Date to Apply
10th February 2025
