Scientist, Antibody Discovery: The Arc Institute invites applications for the position of Scientist, Antibody Discovery in the Horns Lab. The institute is a newly established independent scientific research organization dedicated to curiosity-driven basic science and technology development aimed at understanding and treating complex human diseases.
Located in Palo Alto, the institute collaborates closely with Stanford University, University of California, San Francisco, and University of California, Berkeley. With more than $650 million in committed funding and a rapidly expanding research ecosystem, Arc Institute provides scientists with long-term funding, cutting-edge technology infrastructure, and an environment designed to foster innovative and high-impact research.
This role focuses on developing high-throughput platforms to map human antibody specificities, enabling large-scale profiling of immune repertoires using single-cell sequencing technologies. The selected candidate will collaborate with interdisciplinary teams working in genomics, RNA biology, and AI/ML to advance discoveries in immunology and antibody therapeutics.
Summary Table
| Category | Details |
|---|---|
| Position | Scientist – Antibody Discovery (Horns Lab) |
| Organization | Arc Institute |
| Location | Palo Alto, California, USA |
| Research Area | Immunology, Antibody Discovery, Single-Cell Genomics |
| Qualification | PhD in Immunology/Molecular Biology/Genomics/Bioengineering or related field |
| Experience | 0–5 years post-PhD experience |
| Salary | $121,250 – $159,500 per year + discretionary bonus |
| Job Type | Full-time Research Position |
| Application Mode | Online |
| Last Date | Not specified |
Designation
Scientist – Antibody Discovery (Horns Lab)
Research Area
- Immunology and adaptive immune repertoire analysis
- Antibody discovery and characterization
- Single-cell sequencing technologies
- B cell biology and antigen-specific immune profiling
- Computational analysis of immune sequencing data
- High-throughput screening and sequencing assay development
Location
Palo Alto
Arc Institute Headquarters and Research Facility.
Eligibility / Qualification
Essential Qualifications
- PhD in Immunology, Molecular Biology, Genomics, Bioengineering, or related field.
- 0–5 years of relevant postdoctoral or industry experience.
- Strong expertise in single-cell sequencing technologies for immune profiling (e.g., 10X Genomics VDJ workflows).
- Background in antibody biology, B-cell immunology, or immune repertoire analysis.
- Proficiency in flow cytometry, including multi-parameter panel design and cell sorting.
- Experience with antigen-binding characterization assays such as ELISA, SPR, or BLI.
- Ability to analyze large sequencing datasets using Python, R, or similar tools.
- Experience with mammalian cell culture and molecular biology techniques.
- Excellent communication, project management, and teamwork skills.
Preferred Qualifications
- Experience with antigen-barcoded B cell sequencing approaches (e.g., LIBRA-seq, CITE-seq).
- Expertise in antigen-specific B-cell sorting using labeled antigen probes.
- Experience with human immune cell isolation and culture.
- Knowledge of high-throughput screening, pooled cloning, or library design.
- Experience in protein expression and purification.
- Familiarity with machine learning methods for sequence-function prediction.
Job Description
The selected scientist will contribute to the development and deployment of innovative platforms for large-scale antibody discovery and immune repertoire analysis.
Key Responsibilities
- Develop and optimize a platform for antigen-specific B-cell labeling, sorting, and single-cell sequencing.
- Design and execute validation experiments including antibody cloning and binding confirmation.
- Scale the system for multiplexed antigen library screening.
- Analyze single-cell sequencing data and develop computational analysis pipelines.
- Apply the platform to investigate human immune responses in health and disease.
- Collaborate with Arc’s Technology Centers and interdisciplinary research teams.
- Maintain accurate documentation of experimental protocols and results.
- Present research findings at internal meetings and international conferences.
- Mentor Research Associates and junior scientists.
- Stay updated with advances in single-cell genomics, antibody biology, and immunology research.
Salary and Benefits
- Base Salary: $121,250 – $159,500 per year
- Additional Benefits:
- Annual discretionary performance bonus
- Competitive benefits and research support
- Access to advanced technology platforms and collaborative research environment
How to Apply
Interested candidates must apply online through the Arc Institute careers portal. Applicants are required to submit:
- Updated Resume/CV
- Cover Letter
- Contact information and basic application details
- Optional: LinkedIn profile or professional website
Applicants must also confirm work authorization status in the United States and complete optional demographic self-identification forms.
Last Date to Apply
Not specified (Applications open until the position is filled).
