Sustaining Innovation Post-Doctoral Associate: Astex Pharmaceuticals invites applications for the position of Sustaining Innovation Post-Doctoral Research Associate (SIPD). This unique role offers an exciting opportunity to contribute to cutting-edge research in Neurological Disorders and Oncology using innovative technologies in the field of drug discovery. As part of the Sustaining Innovation team, you will develop novel methodologies for fragment screening and structural characterization of challenging protein targets while collaborating in a multidisciplinary environment.
Sustaining Innovation Post-Doctoral Research Associate
Designation:
Post-Doctoral Research Associate
Key Information
| Details | Description |
|---|---|
| Job Type | Fixed Term Contract |
| Salary | Competitive |
| Start Date | Not Available |
| Hours | Full Time |
| Location | Cambridge, UK |
| Last Date to Apply | 30th September 2025, 23:59 |
| Benefits | Comprehensive benefits package including hybrid working options and onsite facilities on Cambridge Science Park. |
Research Areas:
The research will focus on:
- Fragment screening using covalent approaches and crosslinking chemistries.
- High-resolution structural characterization of protein-fragment complexes using X-ray crystallography and cryo-electron microscopy (cryo-EM).
- Identifying novel binding sites on challenging protein targets such as cryptic pockets and exploring their biological relevance.
Location:
Astex Pharmaceuticals
Cambridge Science Park, 2.5 miles from Cambridge City Centre with excellent transport links to London.
Eligibility/Qualifications:
- Education: Ph.D. in fields such as chemical biology, synthetic organic chemistry, molecular biology, or related subjects.
- Postdoctoral Experience: 1+ year(s) of experience strongly preferred.
- Skills:
- Expertise in one or more areas including:
- Synthetic organic chemistry
- Protein mass spectrometry
- Covalent fragment screening
- Cell-based chemoproteomics
- Biophysical methods
- Protein expression and purification
- X-ray crystallography
- Cryo-electron microscopy (single-particle analysis)
- Proven track record of innovation, complex problem-solving, and research publications in high-impact journals.
- Excellent verbal, written, and scientific communication skills demonstrated at national and international conferences.
- Ability to independently plan and execute research and collaborate effectively within multidisciplinary teams.
Job Description:
Successful candidates will join a dynamic Sustaining Innovation team to:
- Design and implement novel fragment-based drug discovery methodologies.
- Characterize protein-fragment complexes using advanced structural and biophysical tools including X-ray crystallography and cryo-EM.
- Collaborate across diverse scientific disciplines and maintain open communication within a multidisciplinary environment.
- Conduct innovative research and publish in high-impact journals.
Applicants with innovative project ideas within the field are encouraged to submit a one-page proposal outlining their vision as part of their application.
How to Apply:
- Prepare the following documents:
- Curriculum Vitae (CV)
- Maximum 1-page summary of personal innovative project ideas (optional but encouraged).
- Visit the Astex Pharmaceuticals website at https://astx.com to apply and submit your materials.
Last Date to Apply:
30th September 2025, 23:59 (GMT)
Why Join Astex Pharmaceuticals?
Astex Pharmaceuticals is an innovation-driven leader in drug discovery and development, focusing on neurological disorders and oncology. With access to cutting-edge structural biology resources and a commitment to diversity, Astex provides a collaborative and inclusive environment where scientific excellence thrives.
For more information, visit: www.astx.com.
