Summary: Two Postdoctoral Researchers are needed to help build synthetic chromosomes in Professor Tom Ellis’s synthetic biology research group at Imperial College London.
Designation: Research Associate
Research Area: Synthetic Biology, Genome Engineering, Yeast Cell Biology
Location: South Kensington and White City Campus, London (On-site only)
Eligibility/Qualification:
- A PhD in eukaryotic synthetic biology (or equivalent) for appointment at Research Associate level. Applicants close to completion of their PhDs will also be considered where experience is directly relevant.
- Experience with synthetic biology, yeast cell biology, DNA assembly, and genome engineering.
- Familiarity with YACs, HACs and BACs, the yeast cell cycle, mammalian tissue culture, CRISPR-based methods, and recombinase-based genome engineering would all be advantageous.
Job Description:
- Engineer S. cerevisiae yeast strains to tailor their cells for the capture, editing, and transfer of large (250 kb+) sections of synthetic DNA and genomic DNA into artificial chromosomes for use in mammalian tissue culture.
- Engineer yeast strains to accept, stably maintain, and modify large DNA regions from the human genome.
- Modify yeast, via engineering control of their cell cycle, to enable efficient delivery from the yeast cells into the nuclei of cells in tissue culture by cell-to-cell fusion methods.
- Work within a collaborative team project across 5 institutions, co-run technical workshops, share data, tools and methods with relevant stakeholders and engage with those working on ethics and governance projects.
How to Apply: Apply through the Imperial College London online job portal.
Last Date to Apply: July 20, 2025
