Research Officer/Postdoctoral Research: Children’s Medical Research Institute (CMRI) is seeking applications for a Research Officer/Postdoctoral Research Fellow in Molecular Cell Biology. The position, based in Westmead, Sydney NSW, is within the Computational Systems Biology (CSB) lab and focuses on stem cell biology and epigenomics, aiming to understand molecular controls for stem cell-fate decisions.
Designation: Research Officer / Postdoctoral Research Fellow
Research Area: Stem Cell Biology, Epigenomics, Molecular Cell Biology
Location: Westmead, Sydney NSW
Eligibility/Qualification:
- PhD in biological sciences
- Strong background in molecular biology, cell biology, and biochemistry
- Experience in cell culture, experimental design, and high-throughput omics data generation
- Experience in the culture and genetic manipulation of human and mouse stem cells (e.g., by CRISPR/Cas9) is desirable
- Knowledge of epigenomics, stem cell biology, and cellular development
- Knowledge of omics analysis, such as single-cell omics and ChIP-seq, is highly desirable
- Track record of high-quality research output
- Excellent written and oral communication skills
- Evidence of self-motivation and potential for undertaking original research endeavours
- Strong organizational skills, attention to detail, and time management skills
Job Description:
Research Officer / Postdoctoral Research Fellow in Molecular Cell Biology
The role involves conducting wet-lab research in stem cell biology and epigenomics, collaborating with experts in the field, and building a collaboration network. Specific responsibilities include leading research projects, publishing work, presenting scientific results, co-supervising research projects, assisting in recruitment, and building collaborations.
How to Apply: Applications should include a cover letter addressing the selection criteria, a curriculum vitae, and contact details of three professional referees. Direct inquiries to A/Prof Pengyi Yang (pengyi.yang@sydney.edu.au) or Dr Katie Zyner (kzyner@cmri.org.au).
Last Date for Apply: Until position filled
Computational Systems Biology Lab: The position will be jointly mentored by CSB Unit Head A/Prof Pengyi Yang and Senior Postdoctoral Researcher Dr Katie Zyner. The lab specializes in developing computational methods and analyzing omics data generated from stem cells for understanding molecular controls of cell identity and cell-fate decisions.
Research Outputs from the Lab:
- Kim et al. (2023) Comprehensive characterization of fetal and mature retinal cell identity to assess the fidelity of retinal organoids. Stem Cell Reports, 18(1), 175-189.
- Zyner et al. (2022) G-quadruplex DNA structures in human stem cells and differentiation. Nature Communications, 13, 142.
- Kim et al. (2021) Uncovering cell identity through differential stability with Cepo. Nature Computational Science, 1, 784-790.
- Kim et al. (2020) Transcriptional network dynamics during the progression of pluripotency revealed by integrative statistical learning. Nucleic Acids Research, 48(4), 1828-1842.
- Yang et al. (2019) Multi-omic profiling reveals dynamics of the phased progression of pluripotency. Cell Systems, 8(5), 427-445.
- Cinghu, Yang et al. (2017) Intragenic enhancers attenuate host gene expression. Molecular Cell, 68(1), 104-117.
