Research Associate in Chemical Biology: Imperial College London is seeking two ambitious research associates to join the esteemed group of Prof. Ed Tate in the Department of Chemistry, collaborating with the Francis Crick Institute and AstraZeneca. The role focuses on the discovery and optimization of novel molecular glues aimed at advancing therapeutic approaches to tackle various intractable diseases.
Designation
Research Associate
Details
| Title | Research Associate in Chemical Biology |
|---|---|
| Research Area | Chemical Biology, Medicinal Chemistry |
| Location | Francis Crick Institute, London, UK |
| Salary | £48,056 to £56,345 per annum |
| Hours | Full Time |
| Contract Type | Fixed-Term/Contract |
| Placed On | 27th March 2025 |
| Job Reference | NAT01941 |
| Starting Date | On or before 01 October 2025 |
| Application Closing Date | 1st May 2025 |
Eligibility/Qualification
- Hold or near completion of a PhD in Chemical Biology, Medicinal Chemistry, or a closely related field, or possess equivalent qualifications/experience.
- Proven experience in the design and optimization of small molecule ligands.
- Strong research track record relative to experience in academia and/or industry.
- Independent capability and creativity in idea generation and experimental design.
- Ability and willingness to mentor junior researchers and engage in multidisciplinary team settings.
Job Description
As a Research Associate, you will lead the discovery and medicinal chemistry optimization of novel molecular glues identified through various biochemical, computational, structural, and cellular screening technologies. Your responsibilities will include:
- Collaborating with a dynamic team to elucidate the molecular mechanisms of these glues.
- Innovating new modes of molecular glue degrader activity targeting proteins through the ubiquitin-proteasome system or autophagy.
- Driving independent research projects and co-leading collaborative teams.
- Mentoring Master and PhD students within the partnership.
This role presents a unique opportunity to work within a culturally diverse and multidisciplinary environment, contributing to groundbreaking medical research.
How to Apply
Interested candidates should submit their application along with a detailed CV and a cover letter outlining their suitability for the role to Prof. Ed Tate at e.tate@imperial.ac.uk.
Last Date to Apply
Please submit your application by 1st May 2025.
