Postdoctoral Scientist in Membrane Protein: The Division of Structural Biology at the University of Oxford seeks a highly motivated Postdoctoral Research Scientist to join Professor Christian Siebold’s lab. This role supports an Imperial-led Wellcome Trust Discovery Grant focused on understanding the allosteric modulation of class B1 GPCRs through cholesterol binding sites, with implications for metabolic disease therapeutics.
Postdoctoral Research Scientist in Membrane Protein Structural Biology and GPCR Signalling
Designation: Postdoctoral Research Scientist
Research Area: Structural Biology, Membrane Protein Complexes, G Protein Coupled Receptors (GPCRs), Cell Biology
Location:
Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN, UK
Eligibility/Qualification:
- Current PhD/DPhil (or close to completion) in chemistry, biology, or a related field.
- Demonstrable research experience in structural biology of membrane proteins using single-particle cryo-EM, including data collection, processing, and structure solution.
- Experience in mammalian cell culture expression and production of membrane proteins for structural studies is desirable.
Job Description:
As a Postdoctoral Research Scientist, you will:
- Work at the interface of structural biology and cell biology to investigate G protein-coupled receptor complexes.
- Apply techniques such as mammalian protein expression, protein purification, and single-particle cryo-electron microscopy (cryo-EM).
- Participate in experimental design, data interpretation, and dissemination of results through publications and presentations.
- Contribute to the preparation of research reports, funding proposals, and potentially assist in coordinating aspects of the multi-institutional research program.
- Collaborate with a multidisciplinary consortium to study cholesterol-mediated modulation of key receptors relevant to diabetes, obesity, and metabolic disorders.
How to Apply:
Interested candidates should apply online, uploading a supporting statement and CV. The supporting statement must address how you meet the selection criteria for the position, demonstrating your skills and experience with concrete examples. Only CVs and the supporting statement will be considered initially; additional documents may be requested later.
Last Date to Apply:
Applications must be submitted by 12:00 midday on 17 July 2025. Please quote the vacancy ID 179875 in all correspondence.
This post offers an exciting opportunity to work in a vibrant research environment with access to state-of-the-art facilities and strong national and international collaborations.
