Summary
Eli Lilly and Company is seeking a dedicated CADD Postdoctoral Scientist to join its EMD C3 group focused on advancing Synth(on)-Fragment–based Virtual Screening (SFBVS) for early small-molecule drug discovery. This role emphasizes the development of synthesis-aware virtual screening workflows to enhance hit discovery processes.
CADD Postdoctoral Scientist, Seaport Innovation Center, Boston, USA
Designation
CADD Postdoctoral Scientist
Research Area
- Drug Discovery
- Computational Chemistry
- Cheminformatics
- AI in Drug Design
Location
Seaport Innovation Center, Boston
Eligibility/Qualification
- Basic Qualifications:
- PhD in Computational Chemistry, Computer Science, or a related field.
- Strong background in CADD and structure-based drug design.
- Experience with fragment-based drug discovery concepts.
- Proficiency in Python and familiarity with cheminformatics tools (e.g., RDKit).
- Proficiency in DL/ML methods for binding prediction or molecular design.
- Ability to work with large chemical libraries and computational workflows.
- Authorized to work in the United States on a full-time basis.
- Preferred Qualifications:
- Experience with synth(on)- or reaction-based chemical libraries.
- Familiarity with synthetic accessibility scoring, retrosynthesis, or reaction rule systems.
- Experience collaborating with medicinal chemistry teams.
- Strong collaboration and scientific communication skills.
Job Description
The CADD Postdoctoral Scientist will develop and apply synth(on)-fragment–based virtual screening methods for small-molecule hit discovery, focusing on synthesizable chemical space. Key responsibilities include:
- Designing fragment growth, linking, and merging strategies constrained by real-world synthetic feasibility.
- Integrating structure-based modeling with reaction-aware generative designs.
- Prioritizing compounds that balance binding potential, chemical diversity, and synthetic accessibility.
- Collaborating closely with medicinal chemists and screening teams for rapid validation.
- Applying workflows to novel and challenging EMD targets.
How to Apply
Interested candidates should apply through the Eli Lilly careers website by submitting their resume and relevant documents.
Last Date to Apply
Open Now
Please check the Eli Lilly careers website for the specific last date to apply, as this may vary.
Join Eli Lilly in shaping the future of drug discovery while contributing to life-changing medicines.
