Summary
Karolinska Institutet invites applications for a PhD position in the Rydén and Mejhert Laboratory, focusing on the study of human white adipocyte function and its role in cardiometabolic disorders. This position offers a unique opportunity to integrate computational biology with experimental validation to understand post-transcriptional gene regulation.
Doctoral (PhD) Student in Adipocyte Systems Biology, Sweden
Designation
Doctoral (PhD) Student
| Category | Details |
|---|---|
| Research Group | Rydén and Mejhert Laboratory |
| Employment Type | Full-time PhD placement |
| Country | Sweden |
| City | Stockholm |
Research Area
- Adipocyte Systems Biology
- Cardiometabolic Disorders (Type 2 Diabetes, Dyslipidemia, Atherosclerosis)
Location
Karolinska Institutet, Biomedicum and Karolinska University Hospital, Huddinge, Stockholm, Sweden
Eligibility/Qualification
- General Requirement:
- Second-cycle/master qualification (Master’s degree) or equivalent.
- Specific Requirement:
- Proficiency in English equivalent to course English B/English 6 at Swedish upper secondary school.
Job Description
The PhD student will conduct research focusing on:
- Understanding how alternative polyadenylation (APA) regulates gene expression across adipose cell types.
- Developing computational approaches to quantify APA dynamics and infer cell-state trajectories.
- Building analytical frameworks to model transcript isoform selection and cellular transitions.
- Generating a comprehensive atlas of APA in human adipose tissue and identifying regulatory factors influencing metabolic function through experimental validation (e.g., siRNA-mediated knockdown, CRISPR-based gene modulation).
How to Apply
Interested candidates can submit their applications through the Varbi recruitment system. The application must include:
- A personal letter
- A curriculum vitae
- Degree projects and previous publications (if any)
- Documents certifying general and specific eligibility
Last Date to Apply
June 5, 2026
For further inquiries, candidates can contact:
- HR Partner: Anna Heinerö (anna.heinero@ki.se)
- Principal Investigators: Mikael Rydén (mikael.ryden@ki.se), Niklas Mejhert (niklas.mejhert@ki.se)
Don’t miss this opportunity to contribute to groundbreaking research in adipocyte biology!
