Summary
Amsterdam UMC is seeking a motivated Postdoctoral Researcher to contribute to innovative drug discovery for Alzheimer’s disease. This role focuses on developing new therapies targeting APOE4-driven mechanisms within a multidisciplinary research team.
Postdoctoral Researcher in Alzheimer’s Drug Discovery, Amsterdam, Netherlands
Designation
Postdoctoral Researcher
Table: Position Details
| Details | Information |
|---|---|
| Salary | €3.598 – €5.669 gross per month |
| Hours | 36 hours per week |
| Contract Type | Fixed-term |
| Application Deadline | 2 June 2026 |
Research Area
- Drug discovery related to neurodegenerative diseases, particularly Alzheimer’s disease.
Location
Amsterdam UMC, VUmc Campus, Amsterdam, Netherlands
Eligibility/Qualification
- PhD degree or nearing completion in biochemistry, medicinal chemistry, drug development, pharmaceutical sciences, or related fields.
- Experience with biochemical assays and in vitro drug screening approaches.
- Knowledge of high-throughput screening technologies and protein-protein interaction assays preferred.
- Strong analytical skills with the ability to work independently within multidisciplinary collaborations.
- Excellent written and spoken English communication skills.
- Experience with fragment-based drug discovery, DEL screening, or medicinal chemistry approaches is a plus.
Job Description
As a Postdoctoral Researcher, your responsibilities include:
- Establishing biochemical assays for modeling APOE-receptor interactions using recombinant proteins.
- Performing fragment screening and DEL screening to identify compounds disrupting APOE-receptor binding.
- Developing orthogonal biophysical assays to validate candidate compounds.
- Contributing to the preclinical characterization and optimization of identified compounds.
- Collaborating with researchers in biochemistry, medicinal chemistry, and neurodegeneration research across Amsterdam UMC and VU Amsterdam.
- Contributing to scientific publications and presenting research at meetings and conferences.
How to Apply
Interested candidates can apply by submitting their CV and cover letter via the Amsterdam UMC career portal. For inquiries, contact Ruud Wijdeven at r.h.m.wijdeven@amsterdamumc.nl or Chey Edwards at c.i.edwards@amsterdamumc.nl.
Last Date to Apply
2 June 2026
Join our dedicated team to make a significant contribution to Alzheimer’s research and drug discovery!
