Postdoctoral Fellow in Crosslinking: The Webb laboratory at Indiana University – Purdue University Indianapolis (IUPUI) is seeking a highly motivated postdoctoral fellow to join their team. The project focuses on investigating the relationship between conformational preferences of intrinsically disordered proteins (IDPs) and gain or loss of function PTMs/proteoforms and protein-protein interactions, using crosslinking, covalent labeling, and top-down proteomics. The postdoc will also be involved in developing strategies for analyzing crosslinking and covalent labeling top-down data and predicting conformational ensembles of IDPs.
Designation: Postdoctoral Fellow
Research Area: Crosslinking and Top-Down Proteomics
Location: Indiana University – Purdue University Indianapolis (IUPUI), Indianapolis, Indiana, United States
Eligibility/Qualification:
- Ph.D. in Chemistry, Biochemistry, or a related field.
- Experience with protein crosslinking, covalent labeling, top-down mass spectrometry, data analysis, protein expression and purification, ion mobility, or structural and computational biology/biophysics is desirable.
- Strong analytical and problem-solving skills.
- Ability to work independently and collaboratively in a team-oriented environment.
- Excellent communication skills, both written and oral.
- Track record of research productivity, as evidenced by publications in peer-reviewed scientific journals.
Job Description:
- Utilize crosslinking and covalent labeling strategies to probe protein-protein interactions and conformational preferences of intrinsically disordered proteins.
- Employ mass spectrometry techniques, including tandem mass spectrometry with ion mobility, collision-induced dissociation (CID/CAD), electron capture dissociation (ECD), and surface-induced dissociation (ECD).
- Develop and optimize sample preparation and native and denaturing online separation methods.
- Lead the day-to-day administrative operations of the Webb lab.
- Analyze and interpret data, and prepare manuscripts for publication in scientific journals.
- Participate in lab meetings, present research findings at scientific conferences, and assist with training graduate and undergraduate students.
Table: Job Details
| Job ID | 69240113 |
|---|---|
| Workplace Type | On-Site |
| Location | Indianapolis, Indiana, United States |
| Company Name | Indiana University – Purdue University Indianapolis |
| Position Title | Postdoctoral Fellow in Crosslinking and Top-Down Proteomics |
| Area of Expertise | Electrospray Ionization, Fundamentals, Ion Chemistry, LC-MS, Peptide Sequencing, Proteomics |
| Job Role | Post-Doctoral Fellowship |
| Industry | Academic/Research Institution |
| Job Type | Full-Time |
| Job Duration | Indefinite |
| Minimum Education | Ph.D. |
| Minimum Experience | None |
| Required Travel | 0-10% |
How to Apply: Interested candidates should submit the following documents to the designated contact (details mentioned below):
- Cover letter expressing interest in the position
- Curriculum vitae (CV) detailing relevant qualifications and experience
- List of publications
- Contact information of at least three references
Contact: Name: [Provide the designated contact name] Email: [Provide the designated contact email]
Application Deadline: [Specify the application deadline]
Please note that only shortlisted candidates will be contacted for further evaluation and interview.
Note: The initial appointment is for one year with the possibility of renewal based on performance and funding availability.
