Doctoral Researcher (PhD) in Protein Synthesis — University of Helsinki (Fully Funded), Finland

Summary

The University of Helsinki invites applications for a fully funded doctoral researcher (PhD) position in protein synthesis within the O’Keefe lab at the Faculty of Biological and Environmental Sciences, Viikki Campus. This multidisciplinary project combines cellular and chemical biology, cryo-electron microscopy, gene editing and high-throughput screening to discover and repurpose inhibitors of protein synthesis. The appointment is funded for up to 44 months, with an expected start in January 2027 (or as agreed).

Designation

Doctoral Researcher (PhD) in Protein Synthesis

Quick Facts

Research Area and Project Description

This doctoral project, funded by the Research Council of Finland and supervised by Dr Sarah O’Keefe (with co-supervisor Brendan Battersby), explores the early stages of protein synthesis and how newly made polypeptides are translocated and inserted into membranes. The research will integrate:

• Cellular and chemical biology
• Cell-free protein synthesis systems
• Cryo-electron microscopy (cryoEM)
• Gene editing methods
• Orthogonal high-throughput screening for inhibitors

The aim is to identify novel protein synthesis inhibitors and repurpose existing compounds to create tools and lead candidates for treating infectious diseases and cancer, while expanding mechanistic understanding of protein biogenesis.

Location

The position is based at the Viikki Campus, University of Helsinki. The role includes close collaboration with local infrastructures such as the cryoEM Unit, High Throughput Biomedicine Unit and the Finnish Genome Editing Centre, and offers opportunities for short-term research visits (e.g., University of Leeds) and international collaboration.

Eligibility / Qualification

• Master’s degree (or equivalent) in biology, biological sciences, biochemistry, pharmacy or a related field, or completion expected before the start date.
• Motivation for multidisciplinary research and ability to work independently and in a team.
• Strong written and spoken English skills.
• Research experience in laboratory settings is advantageous; specific competencies (cell culture, molecular biology, protein expression/purification, cryoEM) will be learned during the project.
• Merit: prior research experience in industry or a research-intensive academic lab and familiarity with protein synthesis topics.

Scholarship Description & Benefits

The position is a salaried doctoral researcher appointment funded for up to 44 months. The salary is based on the Finnish university pay scale for teaching and research personnel and includes a personal performance component. The University provides:

• Comprehensive occupational healthcare
• Flexible working hours and staff training
• Access to sports facilities and support for international relocation
• Opportunities for conference attendance and international mobility
• Close supervisory support and tailored training as the first doctoral researcher in the lab

Successful applicants are expected to reside in Finland during employment; the University assists international staff with relocation and settling in. Finland offers high-quality public services, education in English, strong family benefits and an excellent quality of life.

Selection Criteria

Ideal candidates will be ambitious, proactive and collegial with a strong interest in multidisciplinary science. The selection will consider academic qualifications, research potential, motivation and ability to learn new techniques. The University will support the selected applicant in applying for the right to pursue a doctoral degree at the University of Helsinki, which must be obtained within the six-month probation period.

How to Apply

Applications must be submitted via the University of Helsinki electronic recruitment system using the “Apply now” link on the job page. Applications by email or other channels will not be accepted. Current University of Helsinki employees should apply via the “Employee login” option.

Prepare a single PDF named lastname_firstname containing the following (submit in the CV field):

• 1 page cover letter describing motivation and suitability
• Curriculum vitae (include publications or manuscripts in preparation)
• Names and contact details of two referees
• Copy of Master’s diploma, or a clear explanation of outstanding studies and timeline to graduate before start date if not yet graduated
• Transcript of records with course details and grading system explanation
• Succinct written responses to four short questions:
  • How does this PhD fit into your career vision and what are alternatives to reach that goal?
  • What do you consider the biggest obstacle for this project?
  • Describe a time when a research task or project failed and how you approached the problem.
  • What are your expectations for supervision, scientific training and professional development?

Note: Except for minor spelling or typographical corrections, the use of AI in preparing application materials will not be evaluated favourably.

Contact & Further Information

For scientific questions about the position, contact Dr Sarah O’Keefe: sarah.okeefe@helsinki.fi.

For technical support with the recruitment system, contact University of Helsinki HR: recruitment@helsinki.fi.

Last Date to Apply

13 November 2026, 23:59 Helsinki time

Apply Link

Submit your application here: University of Helsinki — Doctoral Researcher (PhD) in Protein Synthesis (job posting)

We encourage applications from candidates of diverse backgrounds. Join the O’Keefe lab to contribute to innovative, interdisciplinary research that seeks new ways to understand and target protein synthesis.