Doctorant en Bioinformatique Structurale: A scholarship is available for a doctoral position in structural bioinformatics, focusing on the evolution of proteins. This project aims to develop computational methods for modeling multiple protein conformations and dynamic protein-protein interfaces using evolutionary signals.
Doctorant en Bioinformatique Structurale et Évolution des Protéines
Designation
Doctorant en Bioinformatique Structurale et Évolution des Protéines (H/F)
Research Area
- Structural Bioinformatics
- Protein Evolution
- Computational Modeling
Location
GIF SUR YVETTE, France
Eligibility/Qualification
- Master’s degree in Bioinformatics, Molecular Biology, Computational Biology, or a related field.
- Experience with programming and computational tools, particularly in bioinformatics.
- Knowledge of protein modeling and evolutionary analysis is advantageous.
Description
The doctoral project will involve:
- Developing computational methods to model alternative protein conformations and protein-protein interactions.
- Utilizing AlphaFold2 (AF2) and evolutionary data to enhance predictive modeling.
- Improving a pipeline based on AF2 to explore conformational diversity and studying co-evolution and conservation signals.
- Modeling dynamic protein-protein interfaces, particularly intrinsically disordered regions (IDRs), combining structural templates with innovative scoring methods based on classical statistics and machine learning.
The doctoral candidate will be supervised by Dr. Zea and will be part of the ANR SPPICES project (Scoring and Predicting Protein Interactions and Conformations based on Evolutionary Signals). The environment is multidisciplinary, integrating experimental and computational research, with access to high-performance computing resources.
How to Apply
Candidates must ensure their profiles are correctly filled out before applying. Applications can be submitted through the designated application portal.
Last Date for Apply
September 1, 2025 (00:00:00 Paris time)
