PhD Position – RNA Evolution: Join our dynamic lab at PD POST 10 focused on understanding the constraints of viral evolution at the molecular level. We delve into the intriguing question of why viruses evolve in specific ways, exploring single mutations, RNA structures, genome organization, enzymatic functions, and cellular pathways. Our diverse methodologies, including reverse genetics systems, Next Generation Sequencing (NGS), and proteomics, help unravel the mysteries of viral evolution. We’re also dedicated to developing innovative methods for further investigation.
Table:
| Designation | Research Area | Location |
|---|---|---|
| PhD Position | RNA Virus Evolution and Therapeutic Strategies | PD POST 10 LAB |
Eligibility/Qualification:
- Master’s Degree in Virology, Molecular Biology, Bioinformatics, or similar.
- Experience with viruses is favorable.
- Demonstrable bioinformatics skills (Python, R, etc) are highly desirable.
- Willingness to work in both wet and dry lab environments.
- Fluent in English (oral and written).
- Well-organized and highly motivated to learn.
Job Description:
PhD Position – RNA Virus Evolution and Therapeutic Strategies
The project involves a balance of dry and wet lab work, focusing on enteroviruses and exploring genomic signatures leading to non-homologous recombination. The candidate will generate defective viral genomes (DVGs) and defective interfering particles (DIPs), characterize genomic features regulating these processes, and explore therapeutic approaches. The work includes generating DVGs, utilizing classical virology methods, molecular biology, and various Next Generation Sequencing platforms. Bioinformatic analysis of the generated dataset will be crucial to gaining insights into observed processes, with the ultimate goal of exploring the recoding of viral genomes as a therapeutic platform.
How to Apply: Interested candidates should submit the following documents:
- Motivation letter (explaining interest in the lab and project)
- CV
- Contact details of 2 referees Address applications to Bjorn Meyer, PhD (also for informal inquiries) and send them to bjoern.meyer@gmed.ovg.de.
Last Date for Apply: 31 December 2023
We Offer:
- PhD Position (rn/f/d) 65% TV-L E13 for 3 years
- Possibility to attend (international) conferences
- Potential for (international) collaborations
- Well-equipped BSL-2
- Safe and supportive work environment
References:
- (2021) “Detective viral genomes as therapeutic intervening particles against flavivirus infection in mammalian and mosquito hosts.” Nat Comm.
- (2020) “RNA-seq accuracy and reproducibility for the mapping and quantification of influenza defective viral genomes.” RNA.
- (2021) “Defective Interfering Viral Genomes.” Patent WO2021191688A1.
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