Summary
The group of Fred van Leeuwen at the Netherlands Cancer Institute (NKI) is seeking a motivated PhD candidate to investigate the epigenetic mechanisms of gene regulation in T cells. This project focuses on understanding how targeting the epigenetic writer protein DOT1L can reprogram cytotoxic T cells to enhance their anti-tumor responses. The goal is to uncover new insights into T-cell biology to develop more effective cancer immunotherapies.
Designation
PhD Student
Scholarship Details
| Category | Description |
|---|---|
| Title | PhD Student: Decoding Epigenetic Mechanisms of Gene Regulation in T Cells |
| Research Area | Epigenetic mechanisms of gene regulation in T cells, Cancer Immunology, Molecular Biology |
| Location | Netherlands Cancer Institute (NKI), Amsterdam, Netherlands |
| Duration | 4 years (temporary contract) |
| Salary | Gross monthly salary between €3,813 and €4,629 (based on 36-hour week, OIO scale) |
| Benefits |
|
Research Area
This project will delve into the mechanisms and functions of epigenetic pathways in T cells, specifically focusing on how targeting the epigenetic writer protein DOT1L reprograms cytotoxic T cells. The research aims to understand the epigenetic mechanisms of DOT1L to strengthen T cells for more effective anti-cancer responses. Methodologies will include CRISPR-Cas9 based genome engineering, epigenetic editing, epigenomics, transcriptomics, and DNA-barcode-based epigenetic screens, with validation in primary human CD8 T cells.
Location
Netherlands Cancer Institute (NKI), Amsterdam, Netherlands
Eligibility/Qualification
What can you bring to the job?
- A MSc degree in (molecular) biology or a related discipline (e.g., medical biology, cancer biology, genetics).
- Demonstrable experience with basic molecular biology techniques.
- Affinity for (or ideally experience with) computational biology.
- Fluency in academic English, both spoken and written.
- Prior experience (e.g., internship) in the field of gene regulation / chromatin biology is an asset.
- Interest in fundamental epigenetic mechanisms in the context of cancer immunology.
- Motivated, collaborative, able to work independently, proactive, and problem-solving mindset.
- Excellent social and communication skills for an international and multidisciplinary team.
Scholarship Description
As a PhD candidate at the Antoni van Leeuwenhoek, you will join a cutting-edge, dynamic, and international research environment. You will work within the Division of Gene Regulation, collaborating closely with the Division of Molecular Oncology and Immunology. The NKI provides state-of-the-art core facilities including imaging, flow cytometry, proteomics, genomics, and screening. You will receive training and supervision through the Oncology Graduate School Amsterdam (OOA) and be represented by an active PhD Council. This role offers ample opportunities for scientific, personal, and professional development in an inspiring environment where research and patient care converge.
How to Apply
Interested candidates should apply via the ‘Apply now’ button on the original vacancy page. Your application must include:
- Your application letter, explaining your motivation for this PhD position and highlighting your relevant experience and personal qualities.
- A CV, including your grades. If you have not yet received your MSc certificate, briefly explain what is pending and provide your expected graduation date.
- Contact information for 2 references (name, email address, phone number). Do not submit reference letters.
Important: Ensure that your references’ information and an overview of your grades are attached together with your application letter and CV, as there is no option to submit them separately. Please respond to this vacancy only via the application button, and not via email.
For further information about the position, you may contact Fred van Leeuwen, Group Leader, via fred.v.leeuwen@nki.nl. For questions regarding the application procedure, please contact Pascal van Kippersluis, Recruiter, via p.v.kippersluis@nki.nl.
Last Date for Apply
Applications are open until October 1st. Applications will be assessed on an ongoing basis, so early application is encouraged.
