PhD Studentship: Polymerases: The University of Dundee is offering a funded PhD opportunity under the BBSRC-funded EASTBIO Doctoral Training Partnership to explore the role of poly(ADP-ribosylation) in neuronal function. This research will focus on understanding the mechanisms by which PARylation modifies RNA biogenesis in aging neurons, with potential implications for neurodegenerative diseases.
PhD Studentship: Defining the Neuronal Function of Poly(ADP-Ribose) Polymerases
Designation
PhD Studentship
Research Area
Neuroscience, Molecular Biology, Post-Translational Modifications
Location
University of Dundee, School of Life Sciences
Eligibility/Qualification
- Applicants should have a degree (Honours or Masters equivalent) in a relevant discipline.
- Open to both Home and International students.
| Details | Information |
|---|---|
| Funding | BBSRC funded 4-year studentship |
| Tuition Fees | Covered |
| Annual Stipend | £19,237 (UKRI rate) |
| Start Date | September 2025 |
| Application Deadline | 17 January 2025 |
Description
Poly(ADP-ribosylation), or PARylation, is a reversible post-translational modification crucial for various cellular functions, including neuronal signaling pathways relevant to cancer and neurodegeneration. This PhD project aims to investigate how PARylation regulates RNA-binding proteins in neurons, particularly focusing on TDP-43 and its role in mRNA splicing associated with neuronal survival. The student will utilize advanced techniques in proteomics and transcriptomics to uncover vital neuronal pathways and contribute to significant research in aging and neurodegenerative disease.
How to Apply
Interested candidates should click on the “Apply Now” link to view application guidance and download the application form.
Last Date for Application
17 January 2025
For further inquiries, potential applicants can contact the principal supervisor, Dr. Leeanne McGurk, at lmcgurk001@dundee.ac.uk or call +44 (0)1382 388689.
