Post-doctoral fellow (Bioinformatics) | Thijssen lab, UMC Amsterdam

Postdoc in Netherlands

Post-doctoral fellow (Bioinformatics): We are seeking a motivated and enthusiastic bioinformatician to join the Thijssen lab, contributing to cutting-edge research in the field of Acute Myeloid Leukemia (AML). This position offers a unique opportunity to delve into the molecular basis of leukemia cell plasticity and drug resistance, with a focus on single-cell transcriptomic and epigenomic analyses.

Designation: Post-doctoral fellow (Bioinformatics) | Thijssen lab

Research Area: Acute Myeloid Leukemia (AML), Single-cell transcriptomic and epigenomic analyses, Tumor heterogeneity, Drug resistance mechanisms.

Location: Amsterdam University Medical Centers-Location VUmc

Eligibility/Qualification: Applicants should possess a PhD (or be near completion) in Computational Biology, Bioinformatics, Computer Science, Statistics, or a related field. Strong programming skills in R or Python are required, along with specific experience in analyzing single-cell and functional genomic datasets.

Job Description:

The successful candidate will be involved in a project focused on understanding the mechanisms of resistance to the venetoclax-azacitidine combination in AML. The role will include single-cell and bulk sequencing of AML cells to unravel the non-genetic changes driving drug resistance. The candidate will collaborate closely with experimental biologists, conduct methodological development, analyze large-scale datasets, and contribute to time-series analysis of preclinical models.

Key responsibilities:

  • Conduct single-cell transcriptomic and epigenomic analyses of AML samples.
  • Investigate molecular basis of leukemia cell plasticity in response to venetoclax and/or epigenetic therapy.
  • Collaborate with experimental biologists to design and generate new datasets.
  • Utilize existing genomic resources to direct research focus.

How to Apply: Interested candidates should submit their application, including a cover letter, CV, and contact details of two referees, to Tanja Hart, Recruitment Adviseur, at For questions about the vacancy, contact Tanja Hart at +31621603178.

Last Date for Apply: 19 November 2023


Contract TypeFixed-term
Salary€3.359 – €5.292
Hours36 hours per week
LocationLocatie VUmc
React until19 November 2023
Qualifications requiredSkills and Experience
PhD (or near completion) in relevant fieldStrong programming skills in R or Python
Experience in Computational BiologyAnalytical skills in single-cell and functional genomics
Knowledge of genomics datasetsExperience with pipeline development (advantageous)
Strong communication and interpersonal skillsProven project management experience
BenefitsWork Environment
One-year contract, extendable upon evaluationCollaborative and supportive research team
Salary scale 10: €3.359 to €5.292 grossExtensive network of local and international collaborators
8.3% year-end bonus, 8% holiday allowanceOpportunity to develop new research directions
Pension accrual at BeFrankInclusive and diverse workplace culture
Good accessibility via public transportContribution to translational research in Hematology



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