Post-doctoral fellow (Bioinformatics): We are seeking a motivated and enthusiastic bioinformatician to join the Thijssen lab, contributing to cutting-edge research in the field of Acute Myeloid Leukemia (AML). This position offers a unique opportunity to delve into the molecular basis of leukemia cell plasticity and drug resistance, with a focus on single-cell transcriptomic and epigenomic analyses.
Designation: Post-doctoral fellow (Bioinformatics) | Thijssen lab
Research Area: Acute Myeloid Leukemia (AML), Single-cell transcriptomic and epigenomic analyses, Tumor heterogeneity, Drug resistance mechanisms.
Location: Amsterdam University Medical Centers-Location VUmc
Eligibility/Qualification: Applicants should possess a PhD (or be near completion) in Computational Biology, Bioinformatics, Computer Science, Statistics, or a related field. Strong programming skills in R or Python are required, along with specific experience in analyzing single-cell and functional genomic datasets.
Job Description:
The successful candidate will be involved in a project focused on understanding the mechanisms of resistance to the venetoclax-azacitidine combination in AML. The role will include single-cell and bulk sequencing of AML cells to unravel the non-genetic changes driving drug resistance. The candidate will collaborate closely with experimental biologists, conduct methodological development, analyze large-scale datasets, and contribute to time-series analysis of preclinical models.
Key responsibilities:
- Conduct single-cell transcriptomic and epigenomic analyses of AML samples.
- Investigate molecular basis of leukemia cell plasticity in response to venetoclax and/or epigenetic therapy.
- Collaborate with experimental biologists to design and generate new datasets.
- Utilize existing genomic resources to direct research focus.
How to Apply: Interested candidates should submit their application, including a cover letter, CV, and contact details of two referees, to Tanja Hart, Recruitment Adviseur, at tanja.hart@email.com. For questions about the vacancy, contact Tanja Hart at +31621603178.
Last Date for Apply: 19 November 2023
Tables:
| Contract Type | Fixed-term |
|---|---|
| Salary | €3.359 – €5.292 |
| Hours | 36 hours per week |
| Location | Locatie VUmc |
| React until | 19 November 2023 |
| Qualifications required | Skills and Experience |
|---|---|
| PhD (or near completion) in relevant field | Strong programming skills in R or Python |
| Experience in Computational Biology | Analytical skills in single-cell and functional genomics |
| Knowledge of genomics datasets | Experience with pipeline development (advantageous) |
| Strong communication and interpersonal skills | Proven project management experience |
| Benefits | Work Environment |
|---|---|
| One-year contract, extendable upon evaluation | Collaborative and supportive research team |
| Salary scale 10: €3.359 to €5.292 gross | Extensive network of local and international collaborators |
| 8.3% year-end bonus, 8% holiday allowance | Opportunity to develop new research directions |
| Pension accrual at BeFrank | Inclusive and diverse workplace culture |
| Good accessibility via public transport | Contribution to translational research in Hematology |
Join us : We are seeking a motivated and enthusiastic bioinformatician to join the Thijssen lab, contributing){kind=link}