Post-doctoral fellow (Bioinformatics): We are seeking a motivated and enthusiastic bioinformatician to join the Thijssen lab, contributing to cutting-edge research in the field of Acute Myeloid Leukemia (AML). This position offers a unique opportunity to delve into the molecular basis of leukemia cell plasticity and drug resistance, with a focus on single-cell transcriptomic and epigenomic analyses.
Designation: Post-doctoral fellow (Bioinformatics) | Thijssen lab
Research Area: Acute Myeloid Leukemia (AML), Single-cell transcriptomic and epigenomic analyses, Tumor heterogeneity, Drug resistance mechanisms.
Location: Amsterdam University Medical Centers-Location VUmc
Eligibility/Qualification: Applicants should possess a PhD (or be near completion) in Computational Biology, Bioinformatics, Computer Science, Statistics, or a related field. Strong programming skills in R or Python are required, along with specific experience in analyzing single-cell and functional genomic datasets.
The successful candidate will be involved in a project focused on understanding the mechanisms of resistance to the venetoclax-azacitidine combination in AML. The role will include single-cell and bulk sequencing of AML cells to unravel the non-genetic changes driving drug resistance. The candidate will collaborate closely with experimental biologists, conduct methodological development, analyze large-scale datasets, and contribute to time-series analysis of preclinical models.
- Conduct single-cell transcriptomic and epigenomic analyses of AML samples.
- Investigate molecular basis of leukemia cell plasticity in response to venetoclax and/or epigenetic therapy.
- Collaborate with experimental biologists to design and generate new datasets.
- Utilize existing genomic resources to direct research focus.
How to Apply: Interested candidates should submit their application, including a cover letter, CV, and contact details of two referees, to Tanja Hart, Recruitment Adviseur, at email@example.com. For questions about the vacancy, contact Tanja Hart at +31621603178.
Last Date for Apply: 19 November 2023
|Salary||€3.359 – €5.292|
|Hours||36 hours per week|
|React until||19 November 2023|
|Qualifications required||Skills and Experience|
|PhD (or near completion) in relevant field||Strong programming skills in R or Python|
|Experience in Computational Biology||Analytical skills in single-cell and functional genomics|
|Knowledge of genomics datasets||Experience with pipeline development (advantageous)|
|Strong communication and interpersonal skills||Proven project management experience|
|One-year contract, extendable upon evaluation||Collaborative and supportive research team|
|Salary scale 10: €3.359 to €5.292 gross||Extensive network of local and international collaborators|
|8.3% year-end bonus, 8% holiday allowance||Opportunity to develop new research directions|
|Pension accrual at BeFrank||Inclusive and diverse workplace culture|
|Good accessibility via public transport||Contribution to translational research in Hematology|