Summary
The laboratory of Dr. Ronald Breaker at Yale University invites applications for a Postdoctoral Associate position to participate in a newly funded research program supported by the John Templeton Foundation. This interdisciplinary project focuses on discovering and characterizing novel RNA-based gene regulatory mechanisms in mammals, particularly riboswitches that sense lithium and sodium ions. The successful candidate will investigate how these RNA elements function in eukaryotic cells and explore their roles in neuronal development, ion homeostasis, and human disease.
Postdoctoral Associate in Eukaryotic Cellular Molecular Genetics and RNA Biology, Yale University, USA
Designation
Postdoctoral Associate
Job Details
| Attribute | Details |
| Designation | Postdoctoral Associate |
| Department | Molecular, Cellular and Developmental Biology (MCDB) |
| Institution | Yale University |
| Principal Investigator | Dr. Ronald Breaker |
| Salary | Entry-level starting at $68,500 per year |
| Job Type | Full-Time (1-year initial appointment, renewable annually) |
Research Area
RNA Biology, Genetics, Neuroscience, Human Physiology, and Eukaryotic Cellular Molecular Genetics.
Location
Yale Science Building on Yale’s Science Hill campus, New Haven, CT.
Eligibility/Qualification
Required Qualifications:
- Ph.D. in genetics, molecular biology, cell biology, biochemistry, neuroscience, or a related discipline.
- Strong publication record demonstrating research productivity.
- Experience with mammalian cell culture and molecular genetics.
- Excellent written and oral communication skills.
- Ability to work independently while contributing to a collaborative research environment.
Preferred Qualifications:
- Experience with CRISPR genome engineering.
- Expertise in eukaryotic gene regulation or RNA biology.
- Familiarity with next-generation sequencing approaches and transcriptome analysis.
- Experience with fluorescence reporters, microscopy, or single-cell methods.
- Interest in neurobiology and human disease mechanisms.
Job Description
The postdoctoral researcher will lead experimental studies aimed at validating candidate mammalian riboswitches and defining their biological functions. Key research activities will include:
- Genetic manipulation of mammalian cell lines using CRISPR-based approaches.
- Construction and analysis of reporter systems to monitor RNA-mediated gene regulation.
- Functional characterization of candidate riboswitches in cultured cells.
- Transcriptomic and gene expression analyses.
- Investigation of lithium- and sodium-responsive regulatory pathways.
- Development of cellular models relevant to neuronal biology and neuropsychiatric disorders.
- Collaboration with computational biologists and RNA biochemists within the Breaker laboratory.
How to Apply
Applicants should submit their application materials to Dr. Ron Breaker at ronald.breaker@yale.edu. Please include the following documents:
- A cover letter describing research interests and career goals.
- A curriculum vitae.
- A brief summary of previous research accomplishments.
- Contact information for three references.
Last Date for Apply
Applications will be reviewed on a rolling basis until the position is filled.
