Postdoctoral Associate in Mechanisms of Cell Signalling: The Department of Biochemistry at the University of Oxford invites applications for a Postdoctoral Research Associate position in the Ranes lab. This role focuses on investigating the molecular mechanisms driving the Wnt/beta-catenin signalling pathway at the plasma membrane and offers an exciting opportunity to contribute to groundbreaking research in cell signalling.
Postdoctoral Research Associate in Mechanisms of Cell Signalling
Designation
Postdoctoral Research Associate
Research Area
Mechanisms of Cell Signalling, Wnt/beta-catenin Signalling Pathway
Location
Dorothy Crowfoot Hodgkin Building, Biochemistry Department, South Parks Road, Oxford, OX1 3QU
/Qualification
- Hold a PhD/DPhil or be near completion of a PhD/DPhil in Biochemistry, Cell Biology, or a related discipline.
- Substantial experience in basic molecular biology techniques, particularly recombinant DNA techniques.
- Experience in the expression and purification of recombinant proteins is essential.
- Proficiency in biochemical and biophysical characterization methods.
- Familiarity with mammalian cell culture and associated techniques.
- Strong organizational skills with the ability to prioritize and multitask both independently and collaboratively.
- Excellent oral and written communication skills, with the ability to write for publication and present research proposals and results.
Job Description
The successful candidate will undertake a multidisciplinary approach combining biochemistry, biophysics, cell biology, and structural biology. Responsibilities include:
- Investigating the mechanisms of Wnt pathway activation and termination at the plasma membrane using both in vitro and cell-based approaches.
- Examining the regulation and recruitment of cytoplasmic signal transduction proteins to Wnt receptor complexes.
- Utilizing advanced techniques such as in vitro protein reconstitution, CRISPR approaches, and super-resolution microscopy.
This full-time fixed-term position is funded by the Wellcome Trust for up to 3 years, with a salary range of £41,997 – £46,913 per annum, dependent on qualifications and experience.
How to Apply
Interested applicants should apply online through www.recruit.ox.ac.uk, using Vacancy ID 179455. You will be required to upload your curriculum vitae and a supporting statement outlining how you meet the selection criteria, accompanied by examples of your skills and experience. Additionally, provide details of two referees and indicate whether they can be contacted at this stage.
For further inquiries, please reach out to recruitment@bioch.ox.ac.uk.
Last Date for Application
The closing date for applications is 12:00 noon on Monday, 2nd June 2025. Only applications received before this time will be considered. Interviews for shortlisted candidates will be held as soon as possible thereafter.
