Postdoctoral Fellow: Cancer Metastasis: At Moffitt Cancer Center, we strive to be the leader in understanding the complexity of cancer and applying these insights to contribute to the prevention and cure of cancer. Our diverse team of over 9,000 is dedicated to serving our patients and creating a workspace where every individual is recognized and appreciated. For this reason, Moffitt has been recognized on the 2023 Forbes list of America’s Best Large Employers and America’s Best Employers for Women, Computerworld magazine’s list of 100 Best Places to Work in Information Technology, DiversityInc Top Hospitals & Health Systems and continually named one of the Tampa Bay Time’s Top Workplace. Additionally, Moffitt is proud to have earned the prestigious Magnet® designation in recognition of its nursing excellence. Moffitt is a National Cancer Institute-designated Comprehensive Cancer Center based in Florida and the leading cancer hospital in both Florida and the Southeast. We are a top 10 nationally ranked cancer center by Newsweek and have been nationally ranked by U.S. News & World Report since 1999.
Postdoctoral Research Fellow – Alternative Splicing in Pancreatic Cancer Metastasis
Location: Tampa, FL
Facility: Stabile Research Building (SRB)
Department: Molecular Oncology
Schedule: Full Time – Day Shift – varies
Req #: 76085
Summary
Working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer. Join our committed team and help shape the future we envision.
Postdoctoral Research Fellow: Alternative Splicing in Pancreatic Cancer Metastasis
About the Lab: The Mann lab is dedicated to uncovering novel mechanisms driving pancreatic cancer (PDAC) progression and relapse. Alternative splicing is a process critical to cancer development and mechanisms deregulating splicing during disease progression is an exciting and emerging new area of study in PDAC biology. We recently showed that downregulation of the RNA binding protein RBFOX2 promotes PDAC metastasis through alternative splicing that enhances cytoskeletal remodeling programs promoting cell migration and invasion (Maurin et al., Nature Communications 2023). We are currently dissecting the mechanisms by which RBFOX2-mediated splicing events enhance the oncogenic function of proteins to promote PDAC progression. We are looking for a post-doctoral fellow excited by interdisciplinary science to join our team and contribute to our goal of identifying splicing regulators and specific splicing events in PDAC progression and relapse disease that may be explored for diagnostic or therapeutic efficacy to better treat cancer patients. More information about the lab can be viewed on our website http://labpages2.moffitt.org/mann_k.
Designation: Postdoctoral Research Fellow
Research Area: Alternative Splicing in Pancreatic Cancer Metastasis
Location: Tampa, FL
Eligibility/Qualification: PhD in Genetics, Molecular Biology, Biochemistry or related discipline earned within the last two years.
Job Description:
This position requires molecular biology, cell biology, genomics, proteomics and in vivo modeling approaches to dissect the functions of spliced isoforms of key molecules that modulate cellular processes and signaling pathways driving pancreatic cancer development and metastasis. This individual will work both independently and collaboratively and will be part of a team that consists of basic researchers, clinicians and computational biologists.
The Ideal Candidate:
- Has a strong foundation in molecular biology and cancer biology.
- Is experienced in mammalian cell culture, including 2D and 3D cultures and proficiency in executing phenotypic assays (migration, invasion, colony formation, etc.).
- A background in alternative splicing and/or pancreatic cancer is highly desired.
- Mouse genetics experience and familiarity with NGS is desired but not essential.
Responsibilities:
- Learn research techniques that directly relate to the program’s scientific projects and goals with appropriate direction and supervision.
- Plan, conduct and document experiments independently; evaluate and interpret data with guidance.
- Develop scientific writing and presentation skills, including grant proposals, manuscript preparation and formal seminars presented to the Moffitt scientific community and at national scientific meetings.
How to Apply:
A competitive salary and benefits package will be offered to the successful candidate. Interested applicants should send a single PDF file that includes:
- A current CV with recent publications.
- A personal statement of scientific interests and goals (2-page maximum).
- Contact information for three references.
Please send the application to Dr. Karen Mann at Karen.Mann@moffitt.org.
Last Date for Apply: Until the position is filled.
