Summary
The Faculty of Mathematics and Natural Sciences at University of Cologne is inviting applications for a fully funded Postdoctoral Position in Gene Expression Regulation in the Uhlirova Lab, Institute for Genetics/CECAD. The research group investigates how stress-inducible signaling pathways regulate gene expression and affect tissue homeostasis, ageing, and disease. This is an excellent opportunity for highly motivated researchers to lead independent projects in genetics, molecular biology, and systems biology within a world-class international research environment.
Postdoctoral Position in Gene Expression Regulation at University of Cologne, Germany (2026)
Designation
Postdoctoral Researcher (Gene Expression Regulation) (f/m/x)
Research Area
- Gene Expression Regulation
- Genetics
- Molecular and Cell Biology
- RNA Biology and Pre-mRNA Splicing
- Functional Genomics
- Multi-Omics Research
- Ageing and Tissue Homeostasis
- Bioinformatics and Systems Biology
Location
Uhlirova Lab, Institute for Genetics, CECAD
University of Cologne
Cologne
Eligibility/Qualification
Applicants should possess:
- A completed PhD/Doctoral degree in Biology, Biochemistry, Biophysics, or a related Life Sciences discipline.
- Strong background in genetics, molecular biology, and cell biology.
- Demonstrated ability to conduct independent scientific research.
- Experience working with model organisms, preferably Drosophila and/or mouse models, as well as in vitro systems.
- Excellent written and spoken English communication skills.
- Strong analytical thinking, creativity, and problem-solving abilities.
- Commitment to collaborative and interdisciplinary research.
Desirable Qualifications:
- Experience with multi-omics data generation and analysis.
- Knowledge of iPSC and/or organoid models.
- Expertise in computational modeling of protein–RNA and protein–protein interactions.
- Experience in quantitative image analysis.
- Strong organizational and documentation skills.
Job Description
The selected candidate will investigate fundamental mechanisms governing gene expression regulation and RNA splicing. Key responsibilities include:
- Studying the interaction between transcription and pre-mRNA splicing under normal, stress, and disease conditions.
- Investigating spliceosome assembly mechanisms and functional plasticity.
- Identifying factors that determine transcript, cell, and tissue sensitivity to splicing defects.
- Exploring how spliceosome dysfunction affects genome stability, tissue homeostasis, ageing, and disease.
- Leading an independent research project while contributing to collaborative initiatives within the laboratory.
- Utilizing advanced genetics, molecular biology, microscopy, multi-omics, and bioinformatics approaches.
Scholarship/Position Benefits
- Access to state-of-the-art research facilities.
- International and collaborative research environment.
- Extensive training and professional development opportunities.
- Flexible working arrangements.
- Support for work-life balance.
- Occupational health management programs.
- Equal opportunity and diversity-focused workplace.
Duration & Funding
- Start Date: 1 October 2026
- Appointment Type: Full-time (39.83 hours per week)
- Duration: 2 years (until 30 September 2028)
- Salary: According to TV-L E13 German public sector pay scale, subject to qualifications and experience.
How to Apply
Applicants must submit the following documents through the University of Cologne online application portal:
- Cover letter (maximum one page) describing motivation and research achievements.
- Academic CV (without photograph), including publication list.
- Contact details of three professional references.
- Copies of degree certificates and relevant qualifications.
Reference Number: Wiss2603-13
Apply through the University of Cologne job portal.
Last Date for Apply
📅 15 June 2026
