Postdoctoral Position in Characterizing Inter-Individual Variability in Stress Response and Its Effects on Resilience
Summary
The Institute for Integrative Biology of the Cell (I2BC), Paris-Saclay University, France, invites applications for a fully funded postdoctoral research position in the Autophagy, Stress and Development team, under the supervision of Dr. Renaud Legouis.
The project aims to investigate the molecular mechanisms responsible for individual variability in stress adaptation and their subsequent effects on fitness, health, and resilience. Using the nematode Caenorhabditis elegans (C. elegans) as a model organism, the research will focus on identifying gene regulatory networks and understanding how individuals respond differently to environmental stress, particularly heat stress.
The project will primarily involve transcriptomic analyses, including single-nucleus RNA sequencing (RNA-Seq), experimental work, and bioinformatics. The successful candidate will have access to the advanced sequencing and bioinformatics facilities at I2BC.
The position is fully funded by the ANR-funded InVariStress project (2027–2029), involving two academic laboratories and an industrial Research and Innovation department.
Designation
Postdoctoral Researcher / Postdoctoral Fellow
Research Area
- Autophagy and Cellular Stress Response
- Molecular and Cellular Biology
- Transcriptomics and Single-Cell/Single-Nucleus RNA Sequencing
- Bioinformatics and Computational Biology
- Gene Regulatory Networks
- Developmental Biology
- Stress Adaptation, Resilience, and Aging
Location
Institute for Integrative Biology of the Cell (I2BC)
CNRS, Paris-Saclay University
Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Supervisor: Dr. Renaud Legouis
Research Team: Autophagy, Stress and Development
Eligibility/Qualification
Candidates should meet the following requirements:
- A PhD in Molecular Biology, Cell Biology, Genetics, Bioinformatics, or a closely related discipline.
- Solid experience in global transcriptomic analysis.
- Proficiency in specialized computational tools for transcriptomic data analysis.
- Experience with the C. elegans model organism will be considered a significant advantage.
- Ability to work independently and demonstrate strong research initiative.
- Excellent collaboration and communication skills to work with team members, technological platforms, and external research partners.
- Fluency in English is required.
Job Description
The selected postdoctoral researcher will undertake research activities focused on understanding individual variability in stress responses and its impact on biological resilience.
Key responsibilities include:
- Investigating the molecular mechanisms underlying inter-individual variability in stress adaptation.
- Identifying gene regulatory networks involved in individual responses to environmental stress.
- Conducting transcriptomic analyses, including single-nucleus RNA sequencing.
- Performing experimental studies using C. elegans as a model organism.
- Carrying out bioinformatics and computational analyses of transcriptomic datasets.
- Exploring the effects of stress adaptation on individual fitness, health, and longevity.
- Collaborating with researchers within the team, technological platforms, and external academic and industrial partners.
How to Apply
Interested candidates should submit their applications through the official CNRS recruitment portal.
Required application documents:
- Curriculum Vitae (CV).
- Motivation/Cover Letter.
- Recommendation Letters.
Application Link:
https://emploi.cnrs.fr/Offres/CDD/UMR9198-CHROUL1-165/Default.aspx?lang=EN
Contact Person: Dr. Renaud Legouis
Email: renaud.legouis@i2bc.paris-saclay.fr
Last Date for Apply
Not specified in the announcement. Candidates are encouraged to consult the official CNRS recruitment portal for application deadlines and further details.
Expected Starting Date: Beginning of 2027.
Funding Duration: 2027–2029 (ANR InVariStress Project)
