Research Associate in Gene Delivery: Loughborough University invites applications for an 18-month postdoctoral research associate position in gene delivery and cell biology. This role is part of a collaborative project aiming to develop polymer vesicles for site-specific delivery of CRISPR/Cas9 as a novel therapy for Alzheimer’s Disease.
Research Associate in Gene Delivery and Cell Biology
Designation
Research Associate in Gene Delivery and Cell Biology
Table
| Detail | Information |
|---|---|
| Job Reference | REQ250515 |
| Date Posted | 23/06/2025 |
| Application Closing Date | 20/07/2025 |
| Package | Specialist and Supporting Academic grade 6 from £35,116 to £45,413 per annum, subject to annual pay award. |
| Job Duration | 18 months |
Research Area
Gene Delivery and Cell Biology
Location
Loughborough University
Eligibility/Qualification
- Strong background in biochemistry and/or cell biology.
- Proficiency in mammalian cell culture and microscopy.
- Comfortable performing experiments in controlled/sterile conditions.
- Experience with DNA/RNA, gel electrophoresis, protein expression, and particle sizing techniques is advantageous.
- Ambitious early-career researcher ideal for this role.
Job Description
The successful candidate will join a collaborative team led by Dr. Amanda Pearce. Responsibilities include:
- Screening polymer vesicle formulations to determine optimal chemistries for high encapsulation and stability of CRISPR/Cas9 gene editing constructs.
- Employing a variety of 2D and 3D cell culture assays to assess the selective localization of formulations within diseased brain cells.
- Generating a CRISPR/Cas9 system targeting enhanced green fluorescence protein (GFP).
- Analyzing chemical and biological data to guide further targeted vesicle development.
- Evaluating the ability of hit vesicle formulations to cross the blood-brain barrier using a transwell model with iPSC-derived neurovascular cells.
How to Apply
Candidates interested in applying should submit their application through the university’s online portal. For relevant publications and further details, contact Dr. Amanda Pearce at a.pearce@lboro.ac.uk.
Last Date to Apply
20/07/2025
We encourage applications from individuals of diverse backgrounds and underrepresented groups to contribute to our commitment to an equitable and inclusive environment.
