Postdoctoral Researcher in Protein Quality Control: The Allen Frontiers Group seeks a highly motivated Postdoctoral Researcher to join the Clausen Group in exploring the mechanisms of protein quality control related to disease mutations using C. elegans as a model organism. This position offers an exciting opportunity to investigate proteostasis factors that counteract age-related myopathies and contribute to understanding muscle dysfunction and premature aging.
Designation
Postdoctoral Researcher
Research Area
Molecular Biology, Proteostasis, Protein Quality Control, Muscle Cell Physiology
Location
Research Institute of Molecular Pathology (IMP), Vienna, Austria
Eligibility/Qualification
- A Ph.D. in Molecular Biology, Cell Biology, or a related field.
- Documented experience in C. elegans genetics and molecular biology.
- Proficiency in at least one of the following areas: proteomics, fluorescence microscopy, chemical biology, or structural biology.
- Awareness of proteostasis mechanisms and pathology of protein disorders.
- Excellent teamwork and communication skills.
Job Description
The successful candidate will:
- Conduct genome-wide screens to identify proteostasis factors affecting protein aggregation in muscle cells.
- Perform comparative analyses of proteostasis networks in young versus aged C. elegans.
- Engage in mechanistic studies focusing on ubiquitination factors and autophagy proteins critical for muscle protein homeostasis.
- Utilize patient-derived mutations to investigate how myosin misfolding contributes to muscle dysfunction and aging.
- Employ innovative fluorescent reporters to monitor myosin (mis)folding and degradation in live C. elegans.
How to Apply
Interested candidates should submit the following documents:
- Letter of motivation
- CV including a detailed description of research experience and interests
- Contact information for at least two referees
Applications should be sent to Dr. Tim Clausen at tim.clausen[at]imp.ac.at.
Last Date to Apply
The position is available starting December 2024 and will remain open until filled. Early applications are encouraged.
Join us in a vibrant research community at the IMP and contribute to pioneering work in protein quality control and muscle biology!
