Postdoctoral Associate in of Cell Signalling: The Department of Biochemistry at the University of Oxford is seeking a highly skilled Postdoctoral Research Associate to join the Ranes lab. This position will focus on the molecular mechanisms driving the Wnt/beta-catenin signalling pathway at the plasma membrane, utilizing a multidisciplinary approach incorporating biochemistry, cell biology, and structural biology.
Postdoctoral Research Associate in Mechanisms of Cell Signalling
Designation:
Postdoctoral Research Associate
Research Area:
Cell Signalling, Protein Biochemistry, Molecular Biology
Location:
Dorothy Crowfoot Hodgkin Building, Biochemistry Department, South Parks Road, Oxford, OX1 3QU, UK
Eligibility/Qualification:
- PhD/DPhil or near completion of a PhD/DPhil in Biochemistry, Cell Biology, or a related discipline.
- Substantial experience in basic molecular biology techniques, particularly recombinant DNA techniques.
- Proven experience in the expression and purification of recombinant proteins.
- Familiarity with biochemical and biophysical characterization methods.
- Knowledge and experience in mammalian cell culture and associated cell-based techniques.
- Strong organizational skills, ability to prioritize and multitask lab duties independently and collaboratively.
- Excellent oral and written communication skills, with the capacity to write for publication and present research proposals and results.
Job Description:
In this role, you will build on previous successes in the biochemical reconstitution of the beta-catenin destruction complex. Your primary responsibilities will include:
- Investigating the mechanisms that underpin Wnt pathway activation and termination at the plasma membrane using in vitro and cell-based approaches.
- Studying the regulation and recruitment of cytoplasmic signal transduction proteins to Wnt receptor complexes.
- Utilizing state-of-the-art tools such as in vitro protein reconstitution, CRISPR approaches, and super-resolution microscopy.
This full-time fixed-term position is funded by the Wellcome Trust for up to 3 years.
How to Apply:
Applications for this vacancy must be made online at www.recruit.ox.ac.uk with Vacancy ID 179455. Applicants are required to upload their curriculum vitae and a supporting statement detailing how they meet the selection criteria using relevant examples. Details of two referees must also be provided, alongside an indication of whether they can be contacted immediately.
For any inquiries, please contact recruitment@bioch.ox.ac.uk.
Last Date to Apply:
Applications must be submitted by 12.00 noon on Monday, 2nd June 2025. Only applications received before this time will be considered.
Join us in a vibrant research environment focused on groundbreaking discoveries in cell signaling!
