PhD Opportunity: Synthetic Biology and Biosynthetic Gene Cluster Expression at NTNU, Norway

The Department of Biotechnology and Food Science at the Norwegian University of Science and Technology (NTNU) is offering a fully-funded PhD position focused on synthetic biology and the expression of biosynthetic gene clusters (BGCs). This role is part of the EU-funded AIMARIA project, which aims to accelerate the discovery and production of marine natural products using AI-driven bioprospecting.

PhD Opportunity: Synthetic Biology and Biosynthetic Gene Cluster Expression at NTNU, Norway

Position Overview

Research Area & Project Details

The project focuses on developing predictable and efficient methods for refactoring and heterologous expression of BGCs. You will investigate how regulatory DNA elements, BGC architecture, and host selection influence pathway expression. This involves combining molecular biology and microbial strain engineering with AI-supported design of genetic elements to refine design-build-test-learn cycles.

Key Responsibilities

• Design and construct expression systems for heterologous BGC expression.
• Genetically engineer microbial host strains (e.g., Streptomyces or other actinomycetes).
• Experimentally test promoters, 5′ UTRs, and other regulatory DNA elements.
• Analyze gene expression, transcription, and product formation.
• Collaborate with international partners within the AIMARIA consortium.
• Publish research findings and complete a doctoral thesis.

Eligibility & Qualifications

• Education: Master’s degree (or equivalent, 120 ECTS) in synthetic biology, molecular biology, biotechnology, microbiology, biochemistry, or biochemical engineering.
• Grade Requirements: An average grade of B or better on the NTNU grading scale for your Master’s degree.
• Experience: Practical laboratory experience in molecular biology, genetic engineering, or microbial cultivation.
• Language: Excellent written and oral English skills.
• Note: Candidates currently completing their Master’s may apply, but the degree must be documented before starting (no later than 01.01.2027).

How to Apply

Applications must be submitted electronically via Jobbnorge.no.

Your application must include:

• CV, diplomas, and transcripts of grades.
• A short motivation letter describing your research interests and suitability.
• A copy of your Master’s thesis (or a draft/summary if not yet submitted).
• Contact information for three referees.
• Documentation of education completed outside of Norway (if applicable).

For specific questions regarding the position, you may contact Rahmi Lale (rahmi.lale@ntnu.no) or for the recruitment process, contact Cecilie Skagfjord (cecilie.skagfjord@ntnu.no).

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