Summary
The UNLIMITED (UNderstanding Lipid ImmunoMetabolIsm To trEat Disease) project is a Horizon Europe – Marie Skłodowska-Curie Doctoral Network investigating how lipid metabolism influences immune cell function. This interdisciplinary program trains Doctoral Candidates at the intersection of immunology, metabolism, and advanced technologies to drive breakthroughs in precision medicine.
PhD Opportunity: Shape the Future of Immunometabolism with the UNLIMITED Doctoral Network, luxembourg
Position Details
| Feature | Details |
| Designation | Doctoral Candidate (DC) – PhD Student |
| Research Area | Immunometabolism (Lipid metabolism & T-cell function) |
| Location | Luxembourg Institute of Health, Esch-sur-Alzette |
| Contract Duration | 36 months (Full-time, 40h/week) |
| Start Date | ASAP |
Project Description
You will work on Project #14: Microbial Metabolites as Immune Metabolic Switches: Rewiring Lipid Pathways to Shape T-Cell Function. The primary goal is to determine how microbiome-derived metabolites regulate T-cell lipid metabolism and immune activity.
Key responsibilities include:
- Screening tissue- and microbial-derived metabolites for their impact on T-cell function.
- Analyzing metabolite-induced lipid remodeling using advanced lipidomics and single-cell metabolic profiling (e.g., SCENITH, Met-Flow).
- Utilizing CRISPR/Cas9 to identify and perturb targeted lipid metabolic pathways.
- Validating findings in human systems and preclinical inflammation models.
- Participating in planned secondments at the University Medical Center of Mainz to focus on lipidomics and human T-cell models.
Eligibility & Qualifications
- Education: Master’s degree (or equivalent University Diploma) in a relevant field.
- Degree Status: Must not already possess a doctoral degree at the time of recruitment.
- Mobility Rule: You must not have resided or carried out your main activity (work, studies, etc.) in Luxembourg for more than 12 months in the 36 months immediately preceding the recruitment date.
- Language: Proficiency in English is required for all application documents.
How to Apply
Applications must be submitted in English as one single PDF file (max 5 MB) via the official application portal.
Required Documents:
- Curriculum Vitae: Full CV (max 2 pages, include publications if applicable).
- Cover Letter: (Max 1 page) Detailing research experience and your fit for the topic.
- References: At least two reference letters, plus contact details for two referees.
- Transcripts: B.Sc. and M.Sc. grade transcripts.
- Additional: Relevant certificates (language proficiency, awards, etc.).
Important Note: Applications failing to include all requested documentation or not following the online submission process will not be considered.
Important Information
- Last Date to Apply: Not specified; the position is open and start date is “ASAP.” You are encouraged to apply as soon as possible via the official website.
- Funding: This is a fully funded position with an attractive salary in line with MSCA regulations.
