Summary
The Suyang Zhang Lab at the LMB offers a fully funded PhD position aiming to explore the molecular architecture of co-transcriptional splicing complexes using cryo-electron microscopy (cryo-EM) and biochemical methods. The project seeks to uncover how RNA transcription and splicing are coordinated in human cells.
PhD Position in Cryo-EM and Mechanistic Analysis of Co-Transcriptional Splicing, University of Cambridge, UK
Designation
PhD Student – Research in Molecular Biology and Structural Biology
| Field | Details |
|---|---|
| Research Area | Molecular Biology, Structural Biology |
| Location | Laboratory of Molecular Biology, University of Cambridge |
| Funding | Fully funded |
| Start Date | October 2026 |
Eligibility/Qualification
- A degree in biology, biochemistry, or a related field expected by September 2026.
- Strong interest in molecular biology and structural biology.
- Prior lab experience in molecular biology, protein biochemistry, or structural biology is desirable but not required.
- Open to international applicants.
Description
This PhD project focuses on the essential coordination between transcription and pre-mRNA splicing in eukaryotic cells. The student will investigate the structure and function of large co-transcriptional splicing supercomplexes and dissect the mechanisms that facilitate gene expression. The project will incorporate biochemical, structural, and cellular methods and provide training in:
- Cryo-electron microscopy
- Mammalian cell biology, including CRISPR-Cas9 genome editing
- In vitro reconstitution of large protein-RNA macromolecular complexes
- Biochemical and biophysical assays
The lab emphasizes collaboration and provides access to advanced facilities in cryo-EM, biophysics, and mass spectrometry.
How to Apply
Interested candidates should send the following materials directly to szhang@mrclmb.ac.uk:
- CV
- Statement of interest
- Contact details of two references
Last Date for Application
April 14, 2026 (Applications will be reviewed on a rolling basis).
