Summary
Join a dynamic and innovative research team at Radboud University, focusing on the critical role of synaptic defects in early Alzheimer’s disease (AD). This PhD position offers an exciting opportunity to explore cellular mechanisms behind AD and contribute to the ongoing quest for a deeper understanding of this complex disease.
PhD Scholarship: Finding the Missing Link Between Aβ Exposure and Inhibitory Synaptic Defects, Radboud University, Netherlands
Designation
PhD Candidate
Research Area
Neuroscience, particularly focusing on inhibitory synapses and Alzheimer’s disease mechanisms.
Location
Radboud University, Nijmegen, Netherlands
Eligibility/Qualification
- Degree: Master’s degree in life sciences, biology, biomedical sciences, or related disciplines.
- Experience: Ideally, some experience with advanced microscopy and/or electrophysiology in living brain tissue, and programming skills (e.g., Matlab).
- Skills: Highly motivated, critical, creative, and team-oriented, with a strong interest in intracellular signaling and optical recording methods.
- Language: Proficiency in English (written and spoken) with good communication skills.
Job Description
The PhD candidate will employ single-cell electrophysiology, advanced microscopy, and novel biosensors to characterize synaptic defects at inhibitory synapses in cultured brain slices exposed to amyloid β oligomers. Key responsibilities include:
- Monitoring GABA release alterations with iGABASnFR2 sensors in slices from transgenic mice.
- Assessing molecular and electrophysiological changes related to specific signaling pathways.
- Engaging in a collaborative research environment and potentially undertaking teaching responsibilities (up to 10% of working time).
How to Apply
Interested candidates should apply through the specified application portal by addressing their application letter to Corette Wierenga. Required documentation must accompany the application. For more details on the application process, please refer to the university’s application procedure page.
Last Date to Apply
June 14, 2026
| Component | Details |
|---|---|
| Position | PhD Candidate |
| Salary | €3,059 – €3,881 (gross monthly) |
| Contract Duration | 1.5 years initially (extendable to 4 years) |
| Work Hours | 1.0 FTE (38 hours per week) |
| Teaching Load | Up to 10% |
This scholarship is a fantastic opportunity for aspiring scientists eager to make a significant impact in the field of neuroscience. Apply now and contribute to critical research on Alzheimer’s disease at Radboud University!
