Postdoctoral Fellow Position in RNA Biology, University of Pennsylvania, USA

Summary

The laboratory of Rotem Karni at the Perelman School of Medicine is seeking a highly motivated Postdoctoral Fellow to join a collaborative research team focused on RNA biology and RNA-based therapeutics. The successful candidate will lead innovative research projects exploring alternative splicing, RNA processing, RNA therapeutics, and functional genomics, with applications in cancer, metastasis, and rare genetic diseases. This position offers excellent opportunities for scientific independence, high-impact publications, international conference presentations, and career development.

Postdoctoral Fellow Position in RNA Biology, Alternative Splicing, and RNA Therapeutics

Summary Table

Designation

Postdoctoral Fellow

Research Area

The selected candidate will work on one or more of the following research areas:

• Regulation of alternative splicing by RNA-binding proteins and signaling pathways
• RNA processing programs controlling cell migration, invasion, and tumor progression
• RNA therapeutics, including:
  • Splice-switching oligonucleotides
  • Decoy oligonucleotides
  • Targeted RNA modulation
• m6A-mediated regulation of RNA stability and nonsense-mediated decay
• Functional genomics approaches to identify RNA-based therapeutic vulnerabilities
• Cancer biology, metastasis, and rare genetic diseases

Location

Karni Laboratory
Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania, USA

Eligibility / Qualification

Applicants should possess:

• A PhD or MD/PhD in:
  • Molecular Biology
  • RNA Biology
  • Cancer Biology
  • Genetics
  • Biochemistry
  • Genomics
  • Or a closely related field
• Strong experimental expertise in molecular and cellular biology
• Excellent written and verbal communication skills
• Ability to work independently and within collaborative research teams
• Strong publication record in peer-reviewed journals

Preferred Skills

Experience in one or more of the following areas is advantageous:

• RNA Biology
• Alternative Splicing
• RNA Sequencing (RNA-seq)
• CRISPR Screening Technologies
• Oligonucleotide Therapeutics
• Cancer Models
• Computational Biology and Bioinformatics Analysis

Job Description

The Postdoctoral Fellow will join a dynamic research environment investigating how RNA processing mechanisms regulate gene expression, cell fate decisions, and disease progression.

Key responsibilities include:

• Designing and conducting independent research projects
• Investigating RNA processing mechanisms and alternative splicing regulation
• Applying molecular biology, RNA biochemistry, and cell biology techniques
• Utilizing genomics and functional genomics approaches
• Developing RNA-based therapeutic strategies
• Analyzing and interpreting experimental data
• Publishing research findings in leading scientific journals
• Presenting research at national and international conferences
• Collaborating with multidisciplinary research teams
• Contributing to grant applications and laboratory activities

The position offers strong mentorship and career development support for pursuing future academic or industry research careers.

How to Apply

Interested candidates should submit the following documents:

1. Cover Letter describing:
   • Research interests
   • Career goals
2. Updated Curriculum Vitae (CV)
3. Contact information for three professional references

Send Applications To

Prof. Rotem Karni
Perelman School of Medicine
University of Pennsylvania

Email: rotem.karni@pennmedicine.upenn.edu

Last Date for Apply

Applications will be reviewed immediately and continuously until the position is filled.

Early application is strongly encouraged.

Equal Opportunity Statement

The University of Pennsylvania is an equal opportunity employer and welcomes applications from candidates of diverse backgrounds.